SCHEMBL8938113

SCHEMBL8938113

N#CC(c1ccc(F)cc1)c1cccnc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 5/20 0.53
LMNA P02545 4/20 0.53
ALDH1A1 P00352 3/20 0.53
HPGD P15428 2/20 0.53
USP2 O75604 1/20 0.53
HTT P42858 1/20 0.53
NPSR1 Q6W5P4 1/20 0.53
ALPG P10696 2/20 0.50
CYP19A1 P11511 2/20 0.49
POLB P06746 1/20 0.48
KCNA5 P22460 3/20 0.44
TDP1 Q9NUW8 1/20 0.44
CFTR P13569 1/20 0.42
SLC6A2 P23975 1/20 0.42
SLC6A4 P31645 1/20 0.42
SLC6A3 Q01959 1/20 0.42
GOPC Q9HD26 1/20 0.42
KCNH2 Q12809 1/20 0.41
RPS6KB1 P23443 1/20 0.41
SIGMAR1 Q99720 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2842596 0.86 CFTR (0.57) SMN1; SMN2CYP19A1KCNA5CFTRSLC6A2
SCHEMBL21574585 0.84 KCNA5 (0.45) SMN1; SMN2LMNAALDH1A1HPGDUSP2
SCHEMBL1033928 0.83 CYP19A1 (0.49) SMN1; SMN2LMNAALDH1A1HPGDUSP2
SCHEMBL5052368 0.80 ALDH1A1 (0.74) SMN1; SMN2LMNAALDH1A1HPGDUSP2
SCHEMBL1508006 0.80 ALDH1A1 (0.70) SMN1; SMN2LMNAALDH1A1HPGDUSP2
SCHEMBL1378412 0.77 KCNA5 (0.56) SMN1; SMN2CYP19A1POLBKCNA5CFTR
SCHEMBL11632827 0.77 SLC6A2 (0.70) SMN1; SMN2ALDH1A1NPSR1CYP19A1POLB
SCHEMBL3888426 0.77 KCNA5 (0.56) SMN1; SMN2CYP19A1POLBKCNA5CFTR
Fluorobenzene SCHEMBL1444304 0.76 ALDH1A1 (0.69) SMN1; SMN2LMNAALDH1A1HPGDUSP2
SCHEMBL10371774 0.74 POLB (0.51) SMN1; SMN2CYP19A1POLBKCNA5CFTR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5484787-A Heterocyclicacetonitriles and fungicidal use ROHM AND HAAS COMPANY (US) 1996-01-16 US disclosed
US-5397793-A Heterocyclicacetonitriles and fungicidal use ROHM AND HAAS COMPANY (US) 1995-03-14 US disclosed
EP-0451948-B1 Heterocyclicacetonitriles and their fungicidal use ROHM & HAAS (US) 1994-12-28 EP disclosed
EP-0451948-A1 Heterocyclicacetonitriles and their fungicidal use ROHM AND HAAS COMPANY (US) 1991-10-16 EP disclosed