SCHEMBL21574585

SCHEMBL21574585

N#CC(c1cccnc1)c1cccc(F)c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNA5 P22460 3/20 0.45
KCNH2 Q12809 2/20 0.44
CYP19A1 P11511 3/20 0.43
CFTR P13569 1/20 0.40
SLC6A2 P23975 1/20 0.40
SLC6A4 P31645 1/20 0.40
SLC6A3 Q01959 1/20 0.40
GOPC Q9HD26 1/20 0.40
KDM4E B2RXH2 1/20 0.39
TAAR1 Q96RJ0 1/20 0.39
SMN1; SMN2 Q16637 2/20 0.38
USP2 O75604 1/20 0.37
ALDH1A1 P00352 1/20 0.37
LMNA P02545 1/20 0.37
HPGD P15428 1/20 0.37
HTT P42858 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
ADRB2 P07550 1/20 0.37
ADRB1 P08588 1/20 0.37
ADRB3 P13945 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8938113 0.84 SMN1; SMN2 (0.53) KCNA5KCNH2CYP19A1CFTRSLC6A2
SCHEMBL2842596 0.80 CFTR (0.57) KCNA5CYP19A1CFTRSLC6A2SLC6A4
SCHEMBL27502430 0.78 LMNA (0.57) SMN1; SMN2USP2ALDH1A1LMNAHPGD
SCHEMBL23565933 0.76 TBXAS1 (0.43) CFTRSLC6A2SLC6A4SLC6A3GOPC
SCHEMBL15647598 0.76 SMN1; SMN2 (0.62) KCNA5CFTRSLC6A2SLC6A4SLC6A3
Ammonia Solution, Strong SCHEMBL5998612 0.74 TBXAS1 (0.43) CFTRSLC6A2SLC6A4SLC6A3GOPC
SCHEMBL1033928 0.74 CYP19A1 (0.49) CYP19A1CFTRSLC6A2SLC6A4SLC6A3
SCHEMBL21889466 0.74 ALDH1A1 (0.55) KCNH2TAAR1SMN1; SMN2USP2ALDH1A1
SCHEMBL7678616 0.73 KMT2A (0.46) KCNA5KCNH2SMN1; SMN2ALDH1A1LMNA
SCHEMBL7678624 0.71 AGTR1 (0.46) TAAR1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3057951-B1 METHYLENE LINKED QUINOLINYL MODULATORS OF ROR-GAMMA-T JANSSEN PHARMACEUTICA NV (BE) 2019-11-20 EP disclosed