Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.66 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6795794 | 0.92 | SIGMAR1 (0.64) | HRH3SIGMAR1MAOAMAOB | |
| SCHEMBL6795798 | 0.92 | SIGMAR1 (0.64) | HRH3SIGMAR1MAOAMAOB | |
| SCHEMBL6800161 | 0.92 | SIGMAR1 (0.64) | HRH3SIGMAR1MAOAMAOB | |
| SCHEMBL30291085 | 0.86 | ALDH1A1 (0.66) | HRH3SIGMAR1 | |
| SCHEMBL8938430 | 0.84 | HRH3 (0.69) | HRH3SIGMAR1MEN1KMT2A | |
| SCHEMBL6796835 | 0.83 | SIGMAR1 (0.57) | HRH3SIGMAR1GAA | |
| SCHEMBL4806889 | 0.83 | HRH3 (0.66) | HRH3SIGMAR1NPC1RAB9AMAOA | |
| SCHEMBL6796838 | 0.83 | SIGMAR1 (0.57) | HRH3SIGMAR1GAA | |
| SCHEMBL7355512 | 0.83 | HRH3 (0.66) | HRH3SIGMAR1NPC1RAB9AMAOA | |
| SCHEMBL4806896 | 0.83 | HRH3 (0.66) | HRH3SIGMAR1NPC1RAB9AMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5534626-A | SELECTIVE MUSCARINIC RECEPTOR ANTAGONIST INTERMEDIATES | PFIZER INC. (US) | 1996-07-09 | — | — | US | disclosed |
| US-5410046-A | Selective muscarinic receptor antagonists | PFIZER INC. (US) | 1995-04-25 | — | — | US | disclosed |
| US-5231104-A | Anticholinergic | PFIZER INC. (US) | 1993-07-27 | — | — | US | disclosed |
| EP-0350309-B1 | PIPERIDINE DERIVATIVES | Pfizer Limited (GB) | 1992-11-11 | — | — | EP | disclosed |
| US-5089505-A | Anticholinergic agents | PFIZER INC. (US) | 1992-02-18 | — | — | US | disclosed |
| EP-0350309-A1 | Piperidine derivatives | Pfizer Limited (GB) | 1990-01-10 | — | — | EP | disclosed |