Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 3/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 3/20 | 0.44 |
| ▸ | ARRB1 | P49407 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.43 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8938444 | 0.89 | SLC6A2 (0.47) | OPRK1KCNH2BCHEGRM5GRM7 | |
| SCHEMBL8938402 | 0.89 | OPRM1 (0.51) | OPRM1BCHEGRM5GRM7GRM3 | |
| SCHEMBL8938505 | 0.89 | OPRM1 (0.51) | OPRM1BCHEGRM5GRM7GRM3 | |
| SCHEMBL8938359 | 0.88 | GRM5 (0.50) | OPRK1OPRM1OPRD1BCHEGRM5 | |
| SCHEMBL8938194 | 0.85 | SIGMAR1 (0.49) | OPRK1OPRM1KCNH2SLC6A4CYP2D6 | |
| SCHEMBL8938351 | 0.85 | OPRM1 (0.45) | OPRK1OPRM1OPRD1SLC6A4 | |
| SCHEMBL8938637 | 0.84 | SIGMAR1 (0.51) | OPRM1KCNH2SLC6A4CYP2D6 | |
| SCHEMBL8938341 | 0.83 | HTR2A (0.45) | OPRM1KCNH2SLC6A4CYP2D6 | |
| SCHEMBL8938418 | 0.82 | OPRM1 (0.50) | OPRK1OPRM1KCNH2BCHEGRM5 | |
| SCHEMBL8938424 | 0.81 | HRH3 (0.58) | SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5534626-A | SELECTIVE MUSCARINIC RECEPTOR ANTAGONIST INTERMEDIATES | PFIZER INC. (US) | 1996-07-09 | — | — | US | disclosed |
| US-5266721-A | Process for preparing the pure enantiomers of lifibrol and its alkyl esters | KLINGE PHARMA GMBH (DE) | 1993-11-30 | — | — | US | disclosed |
| US-5231104-A | Anticholinergic | PFIZER INC. (US) | 1993-07-27 | — | — | US | disclosed |
| EP-0518110-A2 | Process for the preparation of pure enatiomers of 4-[4-(4'-tert.butylphenyl)-2-hydroxybutoxy]-benzoic acid and its alkyl ester | Klinge Pharma GmbH (DE) | 1992-12-16 | — | — | EP | disclosed |
| EP-0350309-B1 | PIPERIDINE DERIVATIVES | Pfizer Limited (GB) | 1992-11-11 | — | — | EP | disclosed |
| US-5089505-A | Anticholinergic agents | PFIZER INC. (US) | 1992-02-18 | — | — | US | disclosed |
| EP-0350309-A1 | Piperidine derivatives | Pfizer Limited (GB) | 1990-01-10 | — | — | EP | disclosed |