Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | TUBB4A | P04350 | 10/20 | 0.42 |
| ▸ | TUBB | P07437 | 10/20 | 0.42 |
| ▸ | TUBA3C | P0DPH7 | 10/20 | 0.42 |
| ▸ | TUBA1B | P68363 | 10/20 | 0.42 |
| ▸ | TUBA4A | P68366 | 10/20 | 0.42 |
| ▸ | TUBB4B | P68371 | 10/20 | 0.42 |
| ▸ | TUBB3 | Q13509 | 10/20 | 0.42 |
| ▸ | TUBB2A | Q13885 | 10/20 | 0.42 |
| ▸ | TUBB8 | Q3ZCM7 | 10/20 | 0.42 |
| ▸ | TUBA3E | Q6PEY2 | 10/20 | 0.42 |
| ▸ | TUBA1A | Q71U36 | 10/20 | 0.42 |
| ▸ | TUBA1C | Q9BQE3 | 10/20 | 0.42 |
| ▸ | TUBB6 | Q9BUF5 | 10/20 | 0.42 |
| ▸ | TUBB2B | Q9BVA1 | 10/20 | 0.42 |
| ▸ | TUBB1 | Q9H4B7 | 10/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8938377 | 0.76 | MEN1 (0.62) | MEN1KMT2ASMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL8938380 | 0.75 | MEN1 (0.61) | MEN1KMT2ASMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL28455949 | 0.72 | MEN1 (0.58) | MEN1KMT2ASMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL9685065 | 0.69 | MEN1 (0.54) | MEN1KMT2ASMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL10735550 | 0.69 | TUBB4A (0.53) | MEN1KMT2ASMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL28454399 | 0.69 | TUBB4A (0.61) | MEN1KMT2ATUBB4ATUBBTUBA3C | |
| SCHEMBL8535785 | 0.67 | TUBB4A (0.61) | MEN1KMT2ASMN1; SMN2L3MBTL1TUBB4A | |
| SCHEMBL10740937 | 0.67 | TUBB4A (0.51) | MEN1KMT2ASMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL9684170 | 0.67 | MEN1 (0.51) | MEN1KMT2ASMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL8938276 | 0.67 | MEN1 (0.61) | MEN1KMT2ASMN1; SMN2LMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5527819-A | TREATING AIDS | MERCK & CO., INC. (US) | 1996-06-18 | — | — | US | disclosed |
| EP-0686148-A4 | INHIBITORS OF HIV REVERSE TRANSCRIPTASE | MERCK & CO INC (US) | 1996-02-07 | — | — | EP | disclosed |
| EP-0686148-A1 | INHIBITORS OF HIV REVERSE TRANSCRIPTASE | MERCK & CO. INC. (US) | 1995-12-13 | — | — | EP | disclosed |
| EP-0678508-A1 | Indoles as inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1995-10-25 | — | — | EP | disclosed |
| WO-1994019321-A1 | INHIBITORS OF HIV REVERSE TRANSCRIPTASE | MERCK & CO., INC. (US) | 1994-09-01 | — | — | WO | disclosed |
| WO-1993005020-A1 | INDOLES AS INHIBITORS OF HIV REVERSE TRANSCRIPTASE | MERCK & CO., INC. (US) | 1993-03-18 | — | — | WO | disclosed |
| EP-0530907-A1 | Indoles as inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1993-03-10 | — | — | EP | disclosed |
| US-5124327-A | Administering in the prevention and treatment of AIDS | MERCK & CO., INC. (US) | 1992-06-23 | — | — | US | disclosed |