Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2 | P11137 | 14/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.44 |
| ▸ | TUBB | P07437 | 1/20 | 0.44 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.44 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.44 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.44 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.44 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.44 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.44 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.44 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.44 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.44 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.44 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.44 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.44 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| L-737126 SCHEMBL31654105 | 0.82 | MAP2 (0.61) | MAP2KDM4ETUBB4ATUBBTUBA3C | |
| L-737126 SCHEMBL2344264 | 0.82 | MAP2 (0.61) | MAP2KDM4ETUBB4ATUBBTUBA3C | |
| SCHEMBL2349554 | 0.81 | BRAF (0.52) | MAP2KDM4ETUBB4ATUBBTUBA3C | |
| SCHEMBL8938291 | 0.80 | MAP2 (0.55) | MAP2KDM4ETUBB4ATUBBTUBA3C | |
| SCHEMBL8938269 | 0.80 | MAP2 (0.51) | MAP2TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL8938448 | 0.80 | MAP2 (0.48) | MAP2TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL8938304 | 0.79 | MAP2 (0.59) | MAP2TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL8938370 | 0.79 | TUBB4A (0.61) | MAP2KDM4ETUBB4ATUBBTUBA3C | |
| SCHEMBL8938268 | 0.79 | TUBB4A (0.51) | MAP2KDM4ETUBB4ATUBBTUBA3C | |
| SCHEMBL8938309 | 0.78 | MAP2 (0.58) | MAP2KDM4ETUBB4ATUBBTUBA3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5527819-A | TREATING AIDS | MERCK & CO., INC. (US) | 1996-06-18 | — | — | US | disclosed |
| EP-0686148-A4 | INHIBITORS OF HIV REVERSE TRANSCRIPTASE | MERCK & CO INC (US) | 1996-02-07 | — | — | EP | disclosed |
| EP-0686148-A1 | INHIBITORS OF HIV REVERSE TRANSCRIPTASE | MERCK & CO. INC. (US) | 1995-12-13 | — | — | EP | disclosed |
| WO-1994019321-A1 | INHIBITORS OF HIV REVERSE TRANSCRIPTASE | MERCK & CO., INC. (US) | 1994-09-01 | — | — | WO | disclosed |