Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8938245 | 0.91 | KCNH2 (0.46) | KCNH2HRH3LMNAHPGDHTT | |
| SCHEMBL8938404 | 0.89 | KCNH2 (0.43) | KCNH2HRH3LMNAMEN1CYP2D6 | |
| SCHEMBL8938356 | 0.83 | CCR5 (0.46) | KCNH2HRH3LMNAHPGDMEN1 | |
| SCHEMBL8938317 | 0.81 | HRH3 (0.40) | KCNH2HRH3CYP2D6SLC6A2 | |
| SCHEMBL8938332 | 0.81 | SLC2A1 (0.43) | KCNH2HRH3LMNAMEN1CYP2D6 | |
| SCHEMBL8938187 | 0.80 | CCR5 (0.47) | HRH3SMN1; SMN2 | |
| SCHEMBL8938621 | 0.80 | SIGMAR1 (0.41) | KCNH2HRH3CYP2D6SLC6A2 | |
| SCHEMBL8938514 | 0.80 | HRH3 (0.42) | HRH3 | |
| SCHEMBL8938361 | 0.80 | GBA1 (0.41) | KCNH2HRH3CYP2D6SLC6A2 | |
| SCHEMBL8938226 | 0.80 | HRH3 (0.40) | KCNH2HRH3CYP2D6SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5534626-A | SELECTIVE MUSCARINIC RECEPTOR ANTAGONIST INTERMEDIATES | PFIZER INC. (US) | 1996-07-09 | — | — | US | disclosed |
| US-5410046-A | Selective muscarinic receptor antagonists | PFIZER INC. (US) | 1995-04-25 | — | — | US | disclosed |
| US-5231104-A | Anticholinergic | PFIZER INC. (US) | 1993-07-27 | — | — | US | disclosed |
| EP-0350309-B1 | PIPERIDINE DERIVATIVES | Pfizer Limited (GB) | 1992-11-11 | — | — | EP | disclosed |
| US-5089505-A | Anticholinergic agents | PFIZER INC. (US) | 1992-02-18 | — | — | US | disclosed |
| EP-0350309-A1 | Piperidine derivatives | Pfizer Limited (GB) | 1990-01-10 | — | — | EP | disclosed |