Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 3/20 | 0.41 |
| ▸ | ECE1 | P42892 | 2/20 | 0.37 |
| ▸ | BMP1 | P13497 | 1/20 | 0.37 |
| ▸ | MME | P08473 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 5/20 | 0.35 |
| ▸ | CA1 | P00915 | 4/20 | 0.35 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.35 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.34 |
| ▸ | RIMKLA | Q8IXN7 | 1/20 | 0.33 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8938584 | 1.00 | FOLH1 (0.41) | FOLH1ECE1BMP1MMEKMT2A | |
| SCHEMBL7434672 | 0.88 | FOLH1 (0.47) | FOLH1ECE1CA2CA1CPB2 | |
| SCHEMBL7434665 | 0.88 | FOLH1 (0.47) | FOLH1ECE1CA2CA1CPB2 | |
| SCHEMBL7434561 | 0.86 | TGFBR1 (0.41) | FOLH1MMECA2CA1CPB2 | |
| SCHEMBL7434568 | 0.86 | TGFBR1 (0.41) | FOLH1MMECA2CA1CPB2 | |
| SCHEMBL8938646 | 0.84 | FNTA (0.43) | — | |
| SCHEMBL8938649 | 0.84 | FNTA (0.43) | — | |
| SCHEMBL11333852 | 0.82 | CPB2 (0.53) | FOLH1ECE1BMP1MMEKMT2A | |
| SCHEMBL7431713 | 0.82 | FOLH1 (0.41) | FOLH1MMEKMT2A | |
| SCHEMBL7431705 | 0.82 | FOLH1 (0.41) | FOLH1MMEKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1989012627-A1 | S-NITROSO DERIVATIVES OF ACE INHIBITORS AND THE USE THEREOF | BRIGHAM AND WOMEN'S HOSPITAL (US) | 1989-12-28 | — | — | WO | claimed |
| US-5536723-A | VASODILATORS | BRIGHAM & WOMEN'S HOSPITAL (US) | 1996-07-16 | — | — | US | disclosed |
| US-5356890-A | Angiotensin converting enzyme | BRIGHAM AND WOMEN'S HOSPITAL (US) | 1994-10-18 | — | — | US | disclosed |
| US-5187183-A | Cardiovascular-renal disease; anticoagulants, hypotensive agents; vasodilators; pregnancy toxemia; sclerodema; angiotensin-converting-enzyme inhibitors | BRIGHAM & WOMEN'S HOSPITAL (US) | 1993-02-16 | — | — | US | disclosed |
| WO-1989012627-A1 | S-NITROSO DERIVATIVES OF ACE INHIBITORS AND THE USE THEREOF | BRIGHAM AND WOMEN'S HOSPITAL (US) | 1989-12-28 | — | — | WO | disclosed |