Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 10/20 | 0.46 |
| ▸ | HTR2C | P28335 | 9/20 | 0.46 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 3/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8938706 | 1.00 | HTR2A (0.46) | HTR2AHTR2CKIF11PRMT5EGFR | |
| Hydrochloric Acid SCHEMBL8938525 | 0.99 | HTR2A (0.48) | HTR2AHTR2CKIF11PRMT5EGFR | |
| SCHEMBL8938539 | 0.87 | HTR2A (0.48) | HTR2AHTR2CALDH1A1 | |
| SCHEMBL8938594 | 0.87 | HTR2A (0.48) | HTR2AHTR2CALDH1A1 | |
| SCHEMBL8938622 | 0.85 | HTR2A (0.40) | HTR2AHTR2CKIF11PRMT5EGFR | |
| SCHEMBL8938673 | 0.77 | HTR7 (0.54) | HTR2AHTR2CS1PR1HTR7DRD2 | |
| SCHEMBL8938572 | 0.77 | HTR7 (0.54) | HTR2AHTR2CS1PR1HTR7DRD2 | |
| SCHEMBL9391743 | 0.75 | HTR2A (0.52) | HTR2AHTR2CS1PR1HTR7DRD2 | |
| SCHEMBL9393339 | 0.75 | HTR2A (0.52) | HTR2AHTR2CS1PR1HTR7DRD2 | |
| SCHEMBL8907317 | 0.73 | HTR7 (0.44) | HTR2AHTR2CALDH1A1HTR7DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5538981-A | 5-HYDROXYTRYPTAMINE RECEPTOR ANTAGONIST ACTIVITY | ELI LILLY AND COMPANY (US) | 1996-07-23 | — | — | US | claimed |
| WO-1994024132-A1 | TETRAHYDRO-PYRIDO-INDOLE | ELI LILLY AND COMPANY (US) | 1994-10-27 | — | — | WO | claimed |
| EP-0620223-A2 | Tetrahydro-pyrido-indole | ELI LILLY AND COMPANY (US) | 1994-10-19 | — | — | EP | claimed |
| US-5538981-A | 5-HYDROXYTRYPTAMINE RECEPTOR ANTAGONIST ACTIVITY | ELI LILLY AND COMPANY (US) | 1996-07-23 | — | — | US | disclosed |
| US-5538980-A | CENTRAL NERVOUS SYSTEM | ELI LILLY AND COMPANY (US) | 1996-07-23 | — | — | US | disclosed |
| US-5488053-A | Tetrahydro-pyrido-indole | ELI LILLY AND COMPANY (US) | 1996-01-30 | — | — | US | disclosed |
| WO-1994024132-A1 | TETRAHYDRO-PYRIDO-INDOLE | ELI LILLY AND COMPANY (US) | 1994-10-27 | — | — | WO | disclosed |
| EP-0620223-A2 | Tetrahydro-pyrido-indole | ELI LILLY AND COMPANY (US) | 1994-10-19 | — | — | EP | disclosed |
| US-5300645-A | Condensation of cycloalkyl-, phenyl- or naphthylpyrrole ethylamines with a 2-oxazolidinone to get antiserotonine agent | ELI LILLY AND COMPANY (US) | 1994-04-05 | — | — | US | disclosed |