Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 13/20 | 0.56 |
| ▸ | HTR6 | P50406 | 1/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.44 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.44 |
| ▸ | PRKACA | P17612 | 1/20 | 0.44 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.44 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.44 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.44 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.44 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.44 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.44 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.44 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.44 |
| ▸ | PRKX | P51817 | 1/20 | 0.44 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.44 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.44 |
| ▸ | PARP15 | Q460N3 | 2/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8937112 | 0.89 | HRH1 (0.48) | ROCK1HTR6KMT2A | |
| SCHEMBL8934470 | 0.89 | ROCK1 (0.58) | ROCK1HTR6ROCK2PRKCDPRKACA | |
| SCHEMBL8937109 | 0.87 | HTR6 (0.45) | ROCK1HTR6PARP15PARP10MTNR1A | |
| SCHEMBL8934534 | 0.86 | MAOA (0.50) | ROCK1HTR6ROCK2PRKCDPRKACA | |
| SCHEMBL8938507 | 0.84 | ROCK1 (0.76) | ROCK1HTR6ROCK2PRKCDPRKACA | |
| SCHEMBL8937004 | 0.83 | PARP1 (0.54) | ROCK1HTR6MAOAMAOB | |
| SCHEMBL8937053 | 0.83 | HRH3 (0.47) | ROCK1HTR6MAOAMAOB | |
| SCHEMBL8937018 | 0.82 | HRH3 (0.48) | ROCK1MAOAMAOBKMT2A | |
| SCHEMBL8936996 | 0.82 | MAOA (0.58) | ROCK1HTR6MAOAMAOB | |
| SCHEMBL8938605 | 0.82 | ROCK1 (0.55) | ROCK1HTR6ROCK2PRKCDPRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188117-B2 | Piperidinyl-substituted isoquinolone derivatives | SANOFI-AVENTIS (FR) | 2012-05-29 | — | — | US | disclosed |