SCHEMBL8938757

SCHEMBL8938757

Cc1c[nH]c(=O)c2ccc(OC3CCN(CCC(C)(F)F)CC3)cc12

nearest known ligand 0.56

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ROCK1 Q13464 2/20 0.56
PARP1 P09874 9/20 0.44
MAOA P21397 5/20 0.43
MAOB P27338 5/20 0.43
HRH1 P35367 4/20 0.40
CCR3 P51677 4/20 0.40
KCNH2 Q12809 3/20 0.40
CCR1 P32246 1/20 0.39
ROCK2 O75116 1/20 0.39
PRKACA P17612 1/20 0.39
PRKCD Q05655 1/20 0.39
PRKG1 Q13976 1/20 0.39
PKN1 Q16512 1/20 0.39
PKN2 Q16513 1/20 0.39
AAK1 Q2M2I8 1/20 0.39
CDC42BPA Q5VT25 1/20 0.39
Q6ZSR9 Q6ZSR9 1/20 0.39
BMP2K Q9NSY1 1/20 0.39
CDC42BPB Q9Y5S2 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8935130 0.93 ROCK1 (0.57) ROCK1PARP1MAOAMAOBHRH1
SCHEMBL8938999 0.89 PARP1 (0.43) ROCK1PARP1MAOAMAOBHRH1
SCHEMBL8935088 0.86 ROCK1 (0.58) ROCK1PARP1MAOAMAOBHRH1
SCHEMBL8938826 0.85 HRH1 (0.39) ROCK1PARP1MAOAMAOBHRH1
SCHEMBL8935101 0.85 MAOA (0.60) ROCK1PARP1MAOAMAOBHRH1
SCHEMBL8935086 0.84 ROCK1 (0.60) ROCK1PARP1MAOAMAOBHRH1
SCHEMBL8935120 0.84 PARP1 (0.56) ROCK1PARP1MAOAMAOBHRH1
SCHEMBL8938570 0.83 ROCK1 (0.60) ROCK1PARP1MAOAMAOBROCK2
SCHEMBL8938787 0.83 ROCK1 (0.50) ROCK1PARP1MAOAMAOBHRH1
SCHEMBL8935114 0.82 ROCK1 (0.58) ROCK1PARP1MAOAMAOBHRH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8188117-B2 Piperidinyl-substituted isoquinolone derivatives SANOFI-AVENTIS (FR) 2012-05-29 US disclosed