Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 6/20 | 0.39 |
| ▸ | CCR3 | P51677 | 6/20 | 0.39 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.37 |
| ▸ | MAOA | P21397 | 4/20 | 0.37 |
| ▸ | MAOB | P27338 | 4/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | SCN1A | P35498 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8936820 | 0.94 | ADRB2 (0.43) | HRH1CCR3MAOAMAOBADRB2 | |
| SCHEMBL8936719 | 0.90 | HRH1 (0.42) | HRH1CCR3SCN8AMAOAMAOB | |
| SCHEMBL8936686 | 0.89 | MAOB (0.47) | HRH1CCR3SCN8AMAOAMAOB | |
| SCHEMBL8938976 | 0.88 | HRH1 (0.39) | HRH1CCR3SCN8AMAOAMAOB | |
| SCHEMBL8936664 | 0.88 | SMN1; SMN2 (0.48) | HRH1CCR3SCN8AMAOAMAOB | |
| SCHEMBL8936890 | 0.87 | TEAD1 (0.41) | HRH1CCR3SCN8AMAOAMAOB | |
| SCHEMBL8936773 | 0.86 | HRH1 (0.46) | HRH1CCR3SCN8AMAOAMAOB | |
| SCHEMBL8936704 | 0.85 | HRH1 (0.45) | HRH1CCR3MAOAMAOBSMN1; SMN2 | |
| SCHEMBL8938958 | 0.83 | HRH1 (0.40) | HRH1CCR3MAOAMAOBKCNH2 | |
| SCHEMBL8938967 | 0.83 | HRH1 (0.44) | HRH1CCR3SCN8AMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188117-B2 | Piperidinyl-substituted isoquinolone derivatives | SANOFI-AVENTIS (FR) | 2012-05-29 | — | — | US | disclosed |