Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 12/20 | 0.40 |
| ▸ | CCR3 | P51677 | 12/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8936592 | 0.93 | HRH1 (0.40) | HRH1CCR3KCNH2ROCK1HTR1A | |
| SCHEMBL8939065 | 0.90 | HTR1A (0.37) | HRH1CCR3KCNH2HTR1AMAOA | |
| SCHEMBL8936483 | 0.86 | MAOA (0.46) | HRH1CCR3KCNH2HTR1AMAOA | |
| SCHEMBL8936493 | 0.86 | HRH1 (0.42) | HRH1CCR3KCNH2ROCK1MAOA | |
| SCHEMBL8936546 | 0.85 | HRH1 (0.42) | HRH1CCR3KCNH2HTR1AHTR7 | |
| SCHEMBL8934493 | 0.85 | MAOA (0.39) | HRH1CCR3KCNH2ROCK1MAOA | |
| SCHEMBL8938964 | 0.83 | HRH1 (0.39) | HRH1CCR3KCNH2MAOAMAOB | |
| SCHEMBL8936533 | 0.83 | HRH1 (0.46) | HRH1CCR3KCNH2ROCK1 | |
| SCHEMBL8937203 | 0.83 | HTR1A (0.37) | HRH1CCR3KCNH2HTR1AMAOA | |
| SCHEMBL8936820 | 0.82 | ADRB2 (0.43) | HRH1CCR3KCNH2MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188117-B2 | Piperidinyl-substituted isoquinolone derivatives | SANOFI-AVENTIS (FR) | 2012-05-29 | — | — | US | disclosed |