Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.52 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 4/20 | 0.40 |
| ▸ | DRD4 | P21917 | 4/20 | 0.40 |
| ▸ | DRD3 | P35462 | 3/20 | 0.40 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.38 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8939214 | 0.87 | ROCK1 (0.54) | HRH3ROCK1MEN1KMT2AROCK2 | |
| SCHEMBL14981035 | 0.83 | ROCK1 (0.49) | HRH3ROCK1ROCK2KCNH2LNPEP | |
| SCHEMBL8939216 | 0.83 | MAOA (0.53) | HRH3ROCK1ROCK2KCNH2 | |
| SCHEMBL8148282 | 0.82 | ROCK1 (0.57) | ROCK1ROCK2KCNH2 | |
| SCHEMBL12192815 | 0.79 | HRH3 (0.56) | HRH3ROCK1NAMPTMEN1KMT2A | |
| SCHEMBL12211290 | 0.76 | ROCK1 (0.54) | ROCK1ROCK2KCNH2 | |
| Sar-407899 Free Base SCHEMBL8934240 | 0.76 | ROCK1 (0.72) | HRH3ROCK1ROCK2KCNH2 | |
| SCHEMBL8934755 | 0.76 | ROCK1 (0.62) | HRH3ROCK1MEN1KMT2AROCK2 | |
| SCHEMBL12193225 | 0.75 | NAMPT (0.47) | HRH3ROCK1NAMPTMEN1KMT2A | |
| SCHEMBL4006463 | 0.74 | ROCK1 (0.72) | HRH3ROCK1MEN1KMT2AROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188117-B2 | Piperidinyl-substituted isoquinolone derivatives | SANOFI-AVENTIS (FR) | 2012-05-29 | — | — | US | disclosed |
| US-8188117-B2 | Piperidinyl-substituted isoquinolone derivatives | SANOFI-AVENTIS (FR) | 2012-05-29 | — | — | US | disclosed |