Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.40 |
| ▸ | LIPE | Q05469 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 2/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD5 | P21918 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27492385 | 0.85 | MAOB (0.44) | DRD2HTR1AL3MBTL1MAPTMAPK1 | |
| SCHEMBL8939788 | 0.85 | DRD1 (0.43) | DRD2HTR1AL3MBTL1MAPTHPGD | |
| SCHEMBL27698309 | 0.83 | DRD2 (0.57) | DRD2HTR1AL3MBTL1MAPTMAPK1 | |
| SCHEMBL183414 | 0.82 | MAPT (0.48) | DRD2HTR1AL3MBTL1MAPTMAPK1 | |
| SCHEMBL8859966 | 0.81 | HTR1A (0.43) | DRD2HTR1AL3MBTL1HPGDSMN1; SMN2 | |
| SCHEMBL1616139 | 0.79 | MAPT (0.55) | DRD2HTR1AL3MBTL1MAPTMAPK1 | |
| SCHEMBL10601013 | 0.78 | DRD2 (0.69) | DRD2HTR1AL3MBTL1MAPTMAPK1 | |
| SCHEMBL1691977 | 0.78 | HPGD (0.46) | DRD2HTR1AL3MBTL1MAPTMAPK1 | |
| SCHEMBL7003209 | 0.78 | APP (0.47) | DRD2HTR1AL3MBTL1MAPTMAPK1 | |
| SCHEMBL22325285 | 0.78 | MAPT (0.44) | DRD2HTR1AL3MBTL1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516797-A | SUPPRESSING GRAFT REJECTION | VERTEX PHARMACEUTICALS, INCORPORATED (US) | 1996-05-14 | — | — | US | disclosed |
| US-5330993-A | Immunosuppressive compounds | VERTEX PHARMACEUTICALS, INC. (US) | 1994-07-19 | — | — | US | disclosed |