Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL8940065 | 0.95 | L3MBTL1 (0.56) | L3MBTL1KMT2AMEN1OPRK1 | |
| SCHEMBL8939959 | 0.84 | PARP1 (0.53) | KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL9204228 | 0.83 | PARP1 (0.52) | KMT2AMEN1 | |
| SCHEMBL8939997 | 0.82 | L3MBTL1 (0.60) | L3MBTL1KMT2AMEN1OPRK1 | |
| Tropapride SCHEMBL2110411 | 0.75 | DRD3 (0.79) | L3MBTL1 | |
| SCHEMBL15249477 | 0.73 | KMT2A (0.78) | L3MBTL1KMT2AMEN1OPRK1LMNA | |
| SCHEMBL3595934 | 0.73 | KMT2A (0.78) | L3MBTL1KMT2AMEN1OPRK1LMNA | |
| SCHEMBL16250460 | 0.73 | KMT2A (0.78) | L3MBTL1KMT2AMEN1OPRK1LMNA | |
| SCHEMBL1886766 | 0.73 | KMT2A (0.78) | L3MBTL1KMT2AMEN1OPRK1LMNA | |
| SCHEMBL3595931 | 0.73 | KMT2A (0.78) | L3MBTL1KMT2AMEN1OPRK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5563148-A | BICYCLIC ESTERS OR AMIDES; USED IN TREATING MIGRAINE, EMESIS, GASTROINTESTINAL DISORDERS, SCHIZOPHRENIA OR ANXIETY IN MAMMALS | ELI LILLY AND COMPANY (US) | 1996-10-08 | — | — | US | disclosed |
| EP-0307172-B1 | Improvements in or relating to specific 5-HT3 antagonists | LILLY CO ELI (US) | 1995-10-11 | — | — | EP | disclosed |
| US-5442078-A | Intermediates for specific 5-HT3 antagonists | ELI LILLY AND COMPANY (US) | 1995-08-15 | — | — | US | disclosed |
| US-5364863-A | Treatment of migraine, emesis, schizophrenia, anxiety, gastrointestinal disorders | ELI LILLY AND COMPANY (US) | 1994-11-15 | — | — | US | disclosed |
| US-4997956-A | Analgesics | ELI LILLY AND COMPANY (US) | 1991-03-05 | — | — | US | disclosed |
| US-4921982-A | 5-halo-2,3-dihydro-2,2-dimethylbenzofuran-7-carboxylic acids useful as intermediates for 5-HT3 antagonists | ELI LILLY AND COMPANY (US) | 1990-05-01 | — | — | US | disclosed |
| EP-0307172-A2 | Improvements in or relating to specific 5-HT3 antagonists | ELI LILLY AND COMPANY (US) | 1989-03-15 | — | — | EP | disclosed |