Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CCR3 | P51677 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8940010 | 0.95 | L3MBTL1 (0.61) | L3MBTL1KMT2AMEN1OPRK1 | |
| SCHEMBL8939959 | 0.81 | PARP1 (0.53) | KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL9204228 | 0.80 | PARP1 (0.52) | KMT2AMEN1 | |
| SCHEMBL8939997 | 0.78 | L3MBTL1 (0.60) | L3MBTL1KMT2AMEN1OPRK1 | |
| Tropapride SCHEMBL2110411 | 0.71 | DRD3 (0.79) | L3MBTL1 | |
| SCHEMBL16250460 | 0.70 | KMT2A (0.78) | L3MBTL1KMT2AMEN1OPRK1CYP2D6 | |
| SCHEMBL3595934 | 0.70 | KMT2A (0.78) | L3MBTL1KMT2AMEN1OPRK1CYP2D6 | |
| SCHEMBL15249477 | 0.70 | KMT2A (0.78) | L3MBTL1KMT2AMEN1OPRK1CYP2D6 | |
| SCHEMBL1886766 | 0.70 | KMT2A (0.78) | L3MBTL1KMT2AMEN1OPRK1CYP2D6 | |
| SCHEMBL3595931 | 0.70 | KMT2A (0.78) | L3MBTL1KMT2AMEN1OPRK1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5563148-A | BICYCLIC ESTERS OR AMIDES; USED IN TREATING MIGRAINE, EMESIS, GASTROINTESTINAL DISORDERS, SCHIZOPHRENIA OR ANXIETY IN MAMMALS | ELI LILLY AND COMPANY (US) | 1996-10-08 | — | — | US | disclosed |