Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.80 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | CRHBP | P24387 | 1/20 | 0.50 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.50 |
| ▸ | TDP2 | O95551 | 1/20 | 0.50 |
| ▸ | NSD2 | O96028 | 1/20 | 0.50 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29123133 | 0.89 | TSHR (0.71) | TSHRNOTUMALDH1A1MAPK1MAPT | |
| SCHEMBL14886582 | 0.89 | TSHR (1.00) | TSHRNOTUMALDH1A1MAPK1MAPT | |
| SCHEMBL8940857 | 0.85 | TSHR (0.59) | TSHRALDH1A1MAPK1MAPTLMNA | |
| SCHEMBL182493 | 0.82 | MAPT (0.62) | TSHRALDH1A1MAPK1MAPTLMNA | |
| SCHEMBL3424497 | 0.80 | TSHR (0.66) | TSHRNOTUMALDH1A1MAPK1MAPT | |
| SCHEMBL13367221 | 0.78 | TSHR (0.63) | TSHRNOTUMALDH1A1MAPK1MAPT | |
| SCHEMBL15998949 | 0.78 | TSHR (1.00) | TSHRNOTUMALDH1A1MAPTLMNA | |
| SCHEMBL2162542 | 0.78 | TSHR (0.60) | TSHRALDH1A1MAPK1MAPTLMNA | |
| SCHEMBL15998961 | 0.78 | TSHR (0.79) | TSHRNOTUMALDH1A1MAPK1MAPT | |
| SCHEMBL23174424 | 0.77 | TSHR (0.62) | TSHRALDH1A1MAPK1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5534515-A | Pyrrolopyridazines having gastrointestinal protective effects | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1996-07-09 | — | — | US | disclosed |