Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | CASP7 | P55210 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15998958 | 0.90 | TSHR (0.74) | TSHRGAALMNASMN1; SMN2TDP1 | |
| SCHEMBL8940579 | 0.85 | TSHR (0.80) | TSHRGAALMNASMN1; SMN2TDP1 | |
| SCHEMBL29799301 | 0.77 | KMT2A (0.51) | GAALMNATDP1KDM4EALDH1A1 | |
| SCHEMBL15998969 | 0.77 | NOTUM (0.71) | TSHRGAALMNASMN1; SMN2TDP1 | |
| SCHEMBL15998955 | 0.76 | TSHR (0.73) | TSHRGAALMNASMN1; SMN2TDP1 | |
| SCHEMBL31219110 | 0.76 | PLA2G2A (0.52) | TSHRGAALMNAKDM4EALDH1A1 | |
| SCHEMBL17362788 | 0.76 | MKNK2 (0.55) | GAALMNASMN1; SMN2TDP1KDM4E | |
| SCHEMBL5901603 | 0.76 | FEN1 (0.48) | TSHRGAALMNASMN1; SMN2TDP1 | |
| SCHEMBL15998962 | 0.76 | TSHR (0.78) | TSHRGAALMNASMN1; SMN2TDP1 | |
| SCHEMBL10002706 | 0.74 | MAPT (0.49) | TSHRGAALMNASMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5534515-A | Pyrrolopyridazines having gastrointestinal protective effects | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1996-07-09 | — | — | US | disclosed |