Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | TDP2 | O95551 | 1/20 | 0.46 |
| ▸ | NSD2 | O96028 | 1/20 | 0.46 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17961926 | 0.90 | TSHR (0.55) | TSHRKDM4EMAPTGAAALDH1A1 | |
| SCHEMBL13367221 | 0.89 | TSHR (0.63) | TSHRKDM4ELMNAMAPTGAA | |
| SCHEMBL3424562 | 0.88 | NOTUM (0.60) | TSHRKDM4EGAANOTUMALDH1A1 | |
| SCHEMBL7220431 | 0.84 | TSHR (0.49) | TSHRKDM4EGAAALDH1A1MAOB | |
| SCHEMBL11973871 | 0.83 | TSHR (0.48) | TSHRKDM4ELMNAMAPTGAA | |
| SCHEMBL13339999 | 0.82 | ALDH1A1 (0.48) | TSHRKDM4ELMNAGAAALDH1A1 | |
| SCHEMBL15716479 | 0.81 | CYP1A2 (0.48) | TSHRKDM4ELMNANOTUMALDH1A1 | |
| SCHEMBL8940579 | 0.80 | TSHR (0.80) | TSHRKDM4ELMNAMAPTGAA | |
| SCHEMBL14886582 | 0.80 | TSHR (1.00) | TSHRKDM4ELMNAMAPTGAA | |
| SCHEMBL13339916 | 0.79 | KLKB1 (0.55) | TSHRNOTUMKLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140178503-A1 | CYCLOHEXYL UREA MODULATORS OF D2 RECEPTORS AND/OR D3 RECEPTORS | AUSPEX PHARMACEUTICALS, INC. (US) | 2014-06-26 | — | — | US | disclosed |
| US-7718781-B2 | Hydroxypyridonate and hydroxypyrimidinone chelating agents | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-05-18 | — | — | US | disclosed |
| US-7718781-B2 | Hydroxypyridonate and hydroxypyrimidinone chelating agents | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-05-18 | — | — | US | disclosed |
| EP-1423399-A4 | HYDROXYPYRIDONATE AND HYDROXYPYRIMIDINONE CHELATING AGENTS | UNIV CALIFORNIA (US) | 2008-05-07 | — | — | EP | disclosed |
| WO-2007121453-A2 | 2-HYDROXY-1-OXO 1,2 DIHYDRO ISOQUINOLINE CHELATING AGENTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-10-25 | — | — | WO | disclosed |
| US-6846915-B2 | Hydroxypyridonate and hydroxypyrimidinone chelating agents | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2005-01-25 | — | — | US | disclosed |
| US-20050008570-A1 | Hydroxypyridonate and hydroxypyrimidinone chelating agents | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2005-01-13 | — | — | US | disclosed |
| EP-1423399-A2 | HYDROXYPYRIDONATE AND HYDROXYPYRIMIDINONE CHELATING AGENTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2004-06-02 | — | — | EP | disclosed |
| US-20030095922-A1 | Hydroxypyridonate and hydroxypyrimidinone chelating agents | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2003-05-22 | — | — | US | disclosed |
| WO-2003016923-A2 | HYDROXYPYRIDONATE AND HYDROXYPYRIMIDINONE CHELATING AGENTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2003-02-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050008570-A1 | Hydroxypyridonate and hydroxypyrimidinone chelating agents | HAMP, GDI1, MPI | TSHR 3682/4885KDM4E 732/4885LMNA 2842/4885 |
| US-20140178503-A1 | CYCLOHEXYL UREA MODULATORS OF D2 RECEPTORS AND/OR D3 RECEPTORS | UTS2R, VDR, PTGDR | TSHR 48/4885KDM4E 3737/4885LMNA 4564/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.