SCHEMBL8941280

SCHEMBL8941280

O=[N+]([O-])c1ccc2c(c1)Nc1ccccc1S2

nearest known ligand 0.82

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SNCA P37840 8/20 0.82
NOX1 Q9Y5S8 9/20 0.60
MAPT P10636 4/20 0.55
MEN1 O00255 4/20 0.55
KMT2A Q03164 4/20 0.55
GAA P10253 3/20 0.55
BCHE P06276 2/20 0.55
ACHE P22303 2/20 0.55
ALOX15 P16050 2/20 0.55
CYP1A2 P05177 1/20 0.55
POLB P06746 1/20 0.55
CYP3A4 P08684 1/20 0.55
ADORA3 P0DMS8 1/20 0.55
ALOX12 P18054 1/20 0.55
MAOA P21397 1/20 0.55
CNR1 P21554 1/20 0.55
PTGS1 P23219 1/20 0.55
SLC6A2 P23975 1/20 0.55
HTR2C P28335 1/20 0.55
PTGS2 P35354 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3031049 0.92 SNCA (0.68) SNCANOX1MAPTMEN1KMT2A
SCHEMBL239724 0.90 SNCA (1.00) SNCANOX1MAPTMEN1KMT2A
SCHEMBL30769632 0.90 SNCA (1.00) SNCANOX1MAPTMEN1KMT2A
Phenothiazine SCHEMBL27788701 0.90 SNCA (0.81) SNCANOX1MAPTMEN1KMT2A
SCHEMBL30867073 0.89 SNCA (0.79) SNCANOX1MAPTMEN1KMT2A
SCHEMBL29214094 0.89 SNCA (0.79) SNCANOX1MAPTMEN1KMT2A
SCHEMBL4627484 0.84 SNCA (0.64) SNCANOX1MAPTMEN1KMT2A
SCHEMBL8880299 0.84 SNCA (0.68) SNCANOX1MAPTMEN1KMT2A
SCHEMBL28091598 0.83 SNCA (0.86) SNCANOX1MAPTMEN1KMT2A
SCHEMBL9007278 0.83 SNCA (0.66) SNCANOX1MAPTMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5486582-A Polymer scale preventive process using a coating of chitosan salt and phenothiazine SHIN-ETSU CHEMICAL CO., LTD. (JP) 1996-01-23 US claimed
CN-105669590-A Catalyst-free technique for synthesizing phenothiazine drug intermediate 四川墨凯科技有限公司 2016-06-15 CN disclosed
CN-102532057-A Copper catalytic synthesis phenothiazine compound UNIV CHENGDU TECHNOLOGY 2012-07-04 CN disclosed
US-5486582-A Polymer scale preventive process using a coating of chitosan salt and phenothiazine SHIN-ETSU CHEMICAL CO., LTD. (JP) 1996-01-23 US disclosed