Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10438760 | 0.96 | — | — | |
| SCHEMBL11606199 | 0.77 | PTGS2 (0.34) | — | |
| SCHEMBL31507373 | 0.74 | HTT (0.41) | — | |
| SCHEMBL31512951 | 0.65 | KDM4E (0.47) | — | |
| Bromide SCHEMBL11433371 | 0.64 | POLB (0.68) | — | |
| Bromide SCHEMBL8941023 | 0.61 | TKT (0.54) | — | |
| SCHEMBL1827048 | 0.61 | POLB (0.64) | — | |
| Bromide SCHEMBL8941100 | 0.61 | CA1 (0.31) | — | |
| SCHEMBL13990113 | 0.60 | MAPT (0.39) | — | |
| Hydrochloric Acid SCHEMBL7599736 | 0.60 | POLB (0.62) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3906235-A1 | METHOD FOR PREPARING SULFONAMIDES DRUGS | Ascentage Pharma (Suzhou) Co., Ltd. (CN) | 2021-11-10 | — | — | EP | claimed |
| WO-2020140957-A1 | METHOD FOR PREPARING SULFONAMIDES DRUGS | ASCENTAGE PHARMA (SUZHOU) CO., LTD. (CN) | 2020-07-09 | — | — | WO | claimed |
| EP-3906235-A1 | METHOD FOR PREPARING SULFONAMIDES DRUGS | Ascentage Pharma (Suzhou) Co., Ltd. (CN) | 2021-11-10 | — | — | EP | disclosed |
| WO-2020140957-A1 | METHOD FOR PREPARING SULFONAMIDES DRUGS | ASCENTAGE PHARMA (SUZHOU) CO., LTD. (CN) | 2020-07-09 | — | — | WO | disclosed |
| WO-2018058493-A1 | ORGANIC COMPOUND AND ELECTRONIC DEVICE COMPRISING AN ORGANIC LAYER COMPRISING THE ORGANIC COMPOUND | DOW GLOBAL TECHNOLOGIES LLC (US) | 2018-04-05 | — | — | WO | disclosed |
| EP-3242866-A1 | ORGANIC COMPOUND AND ELECTRONIC DEVICE COMPRISING ORGANIC LAYER COMPRISING THEREOF | Dow Global Technologies LLC (US) | 2017-11-15 | — | — | EP | disclosed |
| EP-3242868-A1 | ORGANIC COMPOUNDS AND ELECTRONIC DEVICE COMPRISING ORGANIC LAYER COMPRISING ORGANIC COMPOUNDS | Dow Global Technologies LLC (US) | 2017-11-15 | — | — | EP | disclosed |
| WO-2016101721-A1 | ORGANIC COMPOUND AND ELECTRONIC DEVICE COMPRISING ORGANIC LAYER COMPRISING THEREOF | DOW GLOBAL TECHNOLOGIES LLC (US) | 2016-06-30 | — | — | WO | disclosed |
| WO-2016101250-A1 | ORGANIC COMPOUND AND ELECTRONIC DEVICE COMPRISING AN ORGANIC LAYER COMPRISING THE ORGANIC COMPOUND | DOW GLOBAL TECHNOLOGIES LLC (US) | 2016-06-30 | — | — | WO | disclosed |
| WO-2016101908-A1 | ORGANIC COMPOUNDS AND ELECTRONIC DEVICE COMPRISING ORGANIC LAYER COMPRISING ORGANIC COMPOUNDS | DOW GLOBAL TECHNOLOGIES LLC (US) | 2016-06-30 | — | — | WO | disclosed |
| US-5580904-A | PENETRATE BLOOD-BRAIN BARRIER | DRUG DELIVERY SYSTEM INSTITUTE, LTD. (JP) | 1996-12-03 | — | — | US | disclosed |
| EP-0614886-B1 | COMPOUND CAPABLE OF INTRACEREBRAL RESIDENCE AND USE THEREOF | DRUG DELIVERY SYSTEM INST LTD (JP) | 1996-10-16 | — | — | EP | disclosed |
| EP-0614886-A1 | COMPOUND CAPABLE OF INTRACEREBRAL RESIDENCE AND USE THEREOF | DRUG DELIVERY SYSTEM INSTITUTE, LTD. (JP) | 1994-09-14 | — | — | EP | disclosed |
| US-5011847-A | 2,5-diaryl tetrahydrofurans and analogs thereof as PAF antagonists | MERCK & CO., INC. (US) | 1991-04-30 | — | — | US | disclosed |