SCHEMBL8941432

SCHEMBL8941432

CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
LTB4R Q15722 20/20 1.00
LTB4R2 Q9NPC1 9/20 0.82

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8941563 0.95 LTB4R (1.00) LTB4RLTB4R2
SCHEMBL8941350 0.94 LTB4R (0.88) LTB4RLTB4R2
SCHEMBL8957165 0.93 LTB4R (0.87) LTB4RLTB4R2
Sc-41390 SCHEMBL29403478 0.90 LTB4R (1.00) LTB4RLTB4R2
Sc-41390 SCHEMBL1889110 0.90 LTB4R (1.00) LTB4RLTB4R2
Sc-41390 SCHEMBL29369604 0.90 LTB4R (1.00) LTB4RLTB4R2
Sc-41390 SCHEMBL6372085 0.90 LTB4R (0.98) LTB4RLTB4R2
SCHEMBL7744035 0.90 LTB4R (1.00) LTB4RLTB4R2
SCHEMBL8957214 0.88 LTB4R (0.88) LTB4RLTB4R2
SCHEMBL9198118 0.88 LTB4R (0.79) LTB4RLTB4R2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0593478-B1 LEUKOTRIENE B 4 ANTAGONISTS SEARLE & CO (US) 1995-12-06 EP claimed
EP-0593478-A1 LEUKOTRIENE B 4? ANTAGONISTS. SEARLE & CO (US) 1994-04-27 EP claimed
US-5124350-A Antiinflammatory agent G. D. SEARLE & CO. (US) 1992-06-23 US claimed
WO-1992000011-A2 LEUKOTRIENE B4 ANTAGONISTS G.D. SEARLE & CO. (US) 1992-01-09 WO claimed
US-5532383-A Leukotriene B4 antagonists G. D. SEARLE & CO. (US) 1996-07-02 US disclosed
US-5516917-A ANTIINFLAMMATORY AGENTS G. D. SEARLE & CO. (US) 1996-05-14 US disclosed
WO-1995033742-A1 LEUKOTRIENE B4 ANTAGONISTS G.D. SEARLE & CO. (US) 1995-12-14 WO disclosed
EP-0593478-B1 LEUKOTRIENE B 4 ANTAGONISTS SEARLE & CO (US) 1995-12-06 EP disclosed
US-5439937-A Leukotriene B4 antagonists G. D. SEARLE & CO. (US) 1995-08-08 US disclosed
US-5310951-A Benzopyran-2-propanoic acid derivatives; antiinflammatory agents G.D. SEARLE & CO. (US) 1994-05-10 US disclosed
EP-0593478-A1 LEUKOTRIENE B 4? ANTAGONISTS. SEARLE & CO (US) 1994-04-27 EP disclosed
US-5124350-A Antiinflammatory agent G. D. SEARLE & CO. (US) 1992-06-23 US disclosed
WO-1992000011-A2 LEUKOTRIENE B4 ANTAGONISTS G.D. SEARLE & CO. (US) 1992-01-09 WO disclosed