Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.37 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.37 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PNMT | P11086 | 1/20 | 0.34 |
| ▸ | XIAP | P98170 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2231457 | 0.84 | NPC1 (0.47) | NPC1RAB9ACES1SRD5A2KDM4E | |
| SCHEMBL8941784 | 0.80 | CES1 (0.36) | NPC1RAB9ACES1SRD5A1SRD5A2 | |
| SCHEMBL25033936 | 0.73 | BCL2L1 (0.47) | MEN1ALDH1A1HPGDKMT2ASMN1; SMN2 | |
| SCHEMBL17154225 | 0.73 | BCL2L1 (0.52) | KDM4EMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL122969 | 0.72 | BCL2L1 (0.50) | NPC1RAB9ACES1SRD5A1SRD5A2 | |
| SCHEMBL27632016 | 0.71 | CES1 (0.41) | NPC1RAB9ACES1SRD5A1SRD5A2 | |
| SCHEMBL20887134 | 0.71 | CES1 (0.41) | NPC1RAB9ACES1SRD5A1SRD5A2 | |
| SCHEMBL26461857 | 0.70 | HTR2B (0.44) | NPC1RAB9ACES1SRD5A2KDM4E | |
| SCHEMBL28163822 | 0.70 | GRM5 (0.38) | KDM4EMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL5907397 | 0.70 | GABRA1 (0.44) | NPC1RAB9ACES1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5480913-A | DIHYDRO-PHENANTHRENE DERIVATIVES, SIDE EFFECT REDUCTION | ARCH DEVELOPMENT CORPORATION (US) | 1996-01-02 | — | — | US | claimed |
| EP-0363128-B1 | ANTI-ANDROGEN COMPOUNDS | ARCH DEVELOPMENT CORPORATION (US) | 1993-09-01 | — | — | EP | claimed |
| EP-0363128-A2 | Anti-androgen compounds | ARCH DEVELOPMENT CORPORATION (US) | 1990-04-11 | — | — | EP | claimed |
| US-5480913-A | DIHYDRO-PHENANTHRENE DERIVATIVES, SIDE EFFECT REDUCTION | ARCH DEVELOPMENT CORPORATION (US) | 1996-01-02 | — | — | US | disclosed |
| EP-0363128-B1 | ANTI-ANDROGEN COMPOUNDS | ARCH DEVELOPMENT CORPORATION (US) | 1993-09-01 | — | — | EP | disclosed |
| US-5208263-A | Dihydrophenanthrene derivatives | ARCH DEVELOPMENT CORPORATION (US) | 1993-05-04 | — | — | US | disclosed |
| WO-1990003979-A2 | ANTI-ANDROGEN COMPOUNDS | ARCH DEVELOPMENT CORPORATION (US) | 1990-04-19 | — | — | WO | disclosed |
| EP-0363128-A2 | Anti-androgen compounds | ARCH DEVELOPMENT CORPORATION (US) | 1990-04-11 | — | — | EP | disclosed |