SCHEMBL8943473

SCHEMBL8943473

NC(=O)c1ccccc1NCNc1ccccc1C(N)=O

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AGTR1 P30556 2/20 0.57
MEN1 O00255 1/20 0.57
KMT2A Q03164 1/20 0.57
KDM4E B2RXH2 7/20 0.51
SIRT2 Q8IXJ6 4/20 0.51
ALDH1A1 P00352 5/20 0.50
HPGD P15428 2/20 0.50
POLB P06746 2/20 0.49
SMN1; SMN2 Q16637 2/20 0.49
PDCD1 Q15116 1/20 0.49
CD274 Q9NZQ7 1/20 0.49
MAPT P10636 2/20 0.48
HSD17B10 Q99714 2/20 0.48
TSHR P16473 1/20 0.48
NPC1 O15118 2/20 0.47
RAB9A P51151 2/20 0.47
SIRT1 Q96EB6 1/20 0.47
TP53 P04637 1/20 0.47
PKM P14618 1/20 0.47
NFKB1 P19838 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3441356 0.84 AGTR1 (0.54) AGTR1MEN1KMT2AKDM4ESIRT2
SCHEMBL14698798 0.84 AGTR1 (0.62) AGTR1MEN1KMT2AKDM4ESIRT2
SCHEMBL17315235 0.82 AGTR1 (0.53) AGTR1MEN1KMT2AKDM4ESIRT2
Hydrochloric Acid SCHEMBL5389527 0.82 AGTR1 (0.53) AGTR1MEN1KMT2AKDM4ESIRT2
SCHEMBL2754257 0.82 HSD17B10 (0.63) AGTR1MEN1KMT2AKDM4ESIRT2
SCHEMBL30311518 0.82 HSD17B10 (0.63) AGTR1MEN1KMT2AKDM4ESIRT2
SCHEMBL1499127 0.82 AGTR1 (0.60) AGTR1MEN1KMT2AKDM4ESIRT2
SCHEMBL4866899 0.82 KDM4E (0.65) AGTR1MEN1KMT2AKDM4ESIRT2
SCHEMBL5392212 0.81 KDM4E (0.58) AGTR1MEN1KMT2AKDM4ESIRT2
SCHEMBL8602088 0.81 AGTR1 (0.55) AGTR1MEN1KMT2AKDM4ESIRT2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5489644-A COMPRISING AROMATIC DIAMINES AND TETRAESTER OF AROMATIC TETRACARBOXYLIC ACID; PROTECTIVE COATING FOR METALS, SILICON WAFERS, GLASS BASF LACKE + FARBEN (DE) 1996-02-06 US disclosed
US-5474876-A Carboxyl-containing polymeric precursor of heterocyclic polymer which is stable at high temperatures and soluble in polar solvents, copolymerizable unsaturated tertiary sulfonium salt, photoinitiator, polar aprotic organic solvent BASF LACKE + FARBEN AG (DE) 1995-12-12 US disclosed
US-5332799-A Aromatic diamines, diesters of aromatic tetracarboxylic acids, circuit coatings BASF LACKE+FARBEN AKTIENGESELLSCHAFT (DE) 1994-07-26 US disclosed
US-5264545-A Aromatic or partly aromatic diamine with tetracarboxylic acid BASF LACKE+FARBEN AKTIENGESELLSCHAFT (DE) 1993-11-23 US disclosed