Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cefaclor Anhydrous. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 1.00 |
| ▸ | MAPT | P10636 | 7/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 6/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 1.00 |
| ▸ | MEN1 | O00255 | 5/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 4/20 | 1.00 |
| ▸ | HPGD | P15428 | 3/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 1.00 |
| ▸ | SLC15A2 | Q16348 | 3/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 1/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 1.00 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 1/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.77 |
| ▸ | BLM | P54132 | 1/20 | 0.77 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.77 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cefaclor Anhydrous SCHEMBL49912 | 1.00 | ALDH1A1 (1.00) | ALDH1A1HSD17B10MAPTKMT2AKDM4E | |
| Cefaclor Anhydrous SCHEMBL33540 | 1.00 | ALDH1A1 (1.00) | ALDH1A1HSD17B10MAPTKMT2AKDM4E | |
| Cefaclor Anhydrous SCHEMBL8626211 | 1.00 | ALDH1A1 (1.00) | ALDH1A1HSD17B10MAPTKMT2AKDM4E | |
| Cefaclor Anhydrous SCHEMBL8524989 | 1.00 | ALDH1A1 (1.00) | ALDH1A1HSD17B10MAPTKMT2AKDM4E | |
| Cefaclor Anhydrous SCHEMBL6155629 | 1.00 | ALDH1A1 (1.00) | ALDH1A1HSD17B10MAPTKMT2AKDM4E | |
| Cefaclor Anhydrous SCHEMBL16072812 | 1.00 | ALDH1A1 (1.00) | ALDH1A1HSD17B10MAPTKMT2AKDM4E | |
| Cefaclor Anhydrous SCHEMBL8478823 | 1.00 | ALDH1A1 (1.00) | ALDH1A1HSD17B10MAPTKMT2AKDM4E | |
| Cefaclor Anhydrous SCHEMBL1006419 | 1.00 | ALDH1A1 (1.00) | ALDH1A1HSD17B10MAPTKMT2AKDM4E | |
| Cefaclor Anhydrous SCHEMBL8626208 | 1.00 | ALDH1A1 (1.00) | ALDH1A1HSD17B10MAPTKMT2AKDM4E | |
| Cefaclor Anhydrous SCHEMBL27281884 | 1.00 | ALDH1A1 (1.00) | ALDH1A1HSD17B10MAPTKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993011132-A1 | METHOD OF PREPARING THE ANTIBIOTIC CEFACLOR | CIBA-GEIGY AG (CH) | 1993-06-10 | — | — | WO | claimed |
| EP-0038626-A1 | A process for electrolytic reduction of cephalosporin p-nitrobenzyl esters | ELI LILLY AND COMPANY (US) | 1981-10-28 | — | — | EP | claimed |
| US-4287181-A | TO ENHANCE THE EFFECTIVENESS OF B-LACTAM ANTIBIOTICS | PFIZER INC. (US) | 1981-09-01 | — | — | US | claimed |
| EP-0730035-A1 | Improved enzymatic process for producing penicillins and cephalosporins | ACS DOBFAR S.p.A. (IT) | 1996-09-04 | — | — | EP | disclosed |
| US-5532353-A | Process for the preparation of halogenated β-lactam compounds | BIOCHIMICA OPOS SPA (IT) | 1996-07-02 | — | — | US | disclosed |
| EP-0570058-A2 | Process for the preparation of halogenated beta-lactam compounds | BIOCHIMICA OPOS SPA (IT) | 1993-11-18 | — | — | EP | disclosed |
| US-4656263-A | 6-β-substituted penicillanic acid compound free of the 6-α-epimer | PFIZER INC. (US) | 1987-04-07 | — | — | US | disclosed |
| US-4518530-A | 6-β-Substituted penicillanic acids as β-lactamase inhibitors | PFIZER INC. (US) | 1985-05-21 | — | — | US | disclosed |
| US-4517126-A | Penicillanic acid derivative | PFIZER INC. (US) | 1985-05-14 | — | — | US | disclosed |
| US-4432970-A | SYNERGISTIC WITH AMINO ACID DERIVATIVE ANTIBIOTICS | PFIZER INC. (US) | 1984-02-21 | — | — | US | disclosed |
| US-4397783-A | HYDRODEHALOGENATION WITH AN ORGANOTIN HYDRIDE | PFIZER INC. (US) | 1983-08-09 | — | — | US | disclosed |
| EP-0083977-A1 | 6-Alpha-hydroxymethylpenicillanic acid sulfone as a beta-lactamase inhibitor | PFIZER INC. (US) | 1983-07-20 | — | — | EP | disclosed |
| US-4338436-A | ANTIBIOTICS | ELI LILLY AND COMPANY (US) | 1982-07-06 | — | — | US | disclosed |
| US-4338439-A | BACTERICIDAL ANTIBIOTICS | ELI LILLY AND COMPANY (US) | 1982-07-06 | — | — | US | disclosed |
| US-4319028-A | 7-(2-(Substituted benzoyl)amino)acetamido)cephalosporins | ELI LILLY AND COMPANY (US) | 1982-03-09 | — | — | US | disclosed |
| US-4287181-A | TO ENHANCE THE EFFECTIVENESS OF B-LACTAM ANTIBIOTICS | PFIZER INC. (US) | 1981-09-01 | — | — | US | disclosed |
| US-4271305-A | ANTIBIOTICS | ELI LILLY AND COMPANY (US) | 1981-06-02 | — | — | US | disclosed |
| US-4226986-A | 7-ACYLAMINO-3-HYDROXY-3-CEPHEM COMPOUND, TRIARYL PHOSPHITE DIHALIDE | ELI LILLY AND COMPANY (US) | 1980-10-07 | — | — | US | disclosed |
| US-4091214-A | ALPHA-HYDROXY CARBOXYLIC ACID | ELI LILLY AND COMPANY (US) | 1978-05-23 | — | — | US | disclosed |