Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPB1 | P04792 | 6/20 | 0.54 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | PRKDC | P78527 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1133767 | 0.86 | TLR4 (0.50) | MAPTLMNATDP1ALDH1A1KDM4E | |
| SCHEMBL5460251 | 0.85 | ERN1 (0.45) | HSPB1MAPTLMNAHTTTDP1 | |
| SCHEMBL11126763 | 0.84 | TDP1 (0.46) | MAPTLMNATDP1ALDH1A1KDM4E | |
| SCHEMBL29115338 | 0.84 | ALDH1A1 (0.42) | MAPTLMNAHTTATMTDP1 | |
| SCHEMBL564611 | 0.82 | ATM (0.60) | HSPB1MAPTLMNAATMTDP1 | |
| SCHEMBL29547124 | 0.82 | ATM (0.60) | HSPB1MAPTLMNAATMTDP1 | |
| SCHEMBL8943775 | 0.82 | MAOB (0.56) | MAPTLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL5457131 | 0.78 | ALDH1A1 (0.61) | MAPTLMNAHTTATMALDH1A1 | |
| SCHEMBL2531644 | 0.78 | HSPB1 (0.57) | HSPB1CRHBPCRHR2MAPTLMNA | |
| SCHEMBL1373865 | 0.78 | HSPB1 (0.57) | HSPB1CRHBPCRHR2MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5541325-A | ENZYME INHIBITORS, ANTIALLERGENS | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-07-30 | — | — | US | disclosed |