Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.53 |
| ▸ | DOT1L | Q8TEK3 | 5/20 | 0.50 |
| ▸ | DNMT3B | Q9UBC3 | 3/20 | 0.50 |
| ▸ | PNMT | P11086 | 2/20 | 0.50 |
| ▸ | DNMT1 | P26358 | 2/20 | 0.50 |
| ▸ | PRMT7 | Q9NVM4 | 2/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | PI4KA | P42356 | 1/20 | 0.46 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.46 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.46 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.46 |
| ▸ | AHCY | P23526 | 2/20 | 0.44 |
| ▸ | NADK | O95544 | 1/20 | 0.44 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.43 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.43 |
| ▸ | TRDMT1 | O14717 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | SUV39H1 | O43463 | 1/20 | 0.43 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.43 |
| ▸ | INMT | O95050 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8943541 | 0.92 | ADORA2A (0.55) | ADORA2ADOT1LDNMT3BPNMTDNMT1 | |
| SCHEMBL5554234 | 0.88 | ADORA2A (0.56) | ADORA2ADOT1LDNMT3BPNMTDNMT1 | |
| SCHEMBL11040343 | 0.87 | ADORA2A (0.58) | ADORA2ADOT1LADORA3PI4KAPI4K2B | |
| SCHEMBL19692161 | 0.87 | ADORA2A (0.58) | ADORA2ADOT1LADORA3PI4KAPI4K2B | |
| SCHEMBL28156591 | 0.85 | ADORA2A (0.64) | ADORA2ADOT1LADORA3PI4KAPI4K2B | |
| SCHEMBL1078828 | 0.85 | ADORA2A (0.64) | ADORA2ADOT1LADORA3PI4KAPI4K2B | |
| SCHEMBL8943859 | 0.85 | ADORA2A (0.52) | ADORA2ADOT1LADORA3PI4KAPI4K2B | |
| SCHEMBL8943715 | 0.84 | ADORA2A (0.57) | ADORA2ADOT1LADORA3PI4KAPI4K2B | |
| SCHEMBL8943533 | 0.84 | ADORA2A (0.53) | ADORA2ADOT1LADORA3PI4KAPI4K2B | |
| SCHEMBL9054202 | 0.82 | ADORA2A (0.55) | ADORA2ADOT1LADORA3PI4KAPI4K2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5563125-A | 5'-deoxy-5'-(substituted)alkylthioribose compounds and their pharmaceutical compositions | HEALTH RESEARCH, INC. (US) | 1996-10-08 | — | — | US | disclosed |
| EP-0555352-A1 | AGENTS FOR THE TREATMENT OF DISEASES CAUSED BY PARASITIC PROTOZOA AND NEOPLASTIC DISEASES | HEALTH RESEARCH, INC. (US) | 1993-08-18 | — | — | EP | disclosed |
| US-5180714-A | ADENOSINE COMPOUNDS FOR THE TREATMENT OF DISEASES CAUSED BY PARASITIC PROTOZOA | HEALTH RESEARCH, INC. (US) | 1993-01-19 | — | — | US | disclosed |
| WO-1992007570-A1 | AGENTS FOR THE TREATMENT OF DISEASES CAUSED BY PARASITIC PROTOZOA AND NEOPLASTIC DISEASES | HEALTH RESEARCH, INC. (US) | 1992-05-14 | — | — | WO | disclosed |