Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 5/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.52 |
| ▸ | PI4KA | P42356 | 2/20 | 0.48 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.48 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.48 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.48 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.44 |
| ▸ | HSP90B1 | P14625 | 2/20 | 0.44 |
| ▸ | AHCY | P23526 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28156591 | 0.88 | ADORA2A (0.64) | ADORA2AADORA3PI4KAPI4K2BPI4K2A | |
| SCHEMBL19692161 | 0.88 | ADORA2A (0.58) | ADORA2AADORA3PI4KAPI4K2BPI4K2A | |
| SCHEMBL1078828 | 0.88 | ADORA2A (0.64) | ADORA2AADORA3PI4KAPI4K2BPI4K2A | |
| SCHEMBL11040343 | 0.88 | ADORA2A (0.58) | ADORA2AADORA3PI4KAPI4K2BPI4K2A | |
| SCHEMBL8943715 | 0.87 | ADORA2A (0.57) | ADORA2AADORA3PI4KAPI4K2BPI4K2A | |
| SCHEMBL5554234 | 0.86 | ADORA2A (0.56) | ADORA2AADORA3PI4KAPI4K2BPI4K2A | |
| SCHEMBL8943533 | 0.82 | ADORA2A (0.53) | ADORA2AADORA3PI4KAPI4K2BPI4K2A | |
| SCHEMBL8943541 | 0.82 | ADORA2A (0.55) | ADORA2AADORA3PI4KAPI4K2BPI4K2A | |
| SCHEMBL8943868 | 0.82 | ADORA2A (0.53) | ADORA2AADORA3PI4KAPI4K2BPI4K2A | |
| SCHEMBL25408738 | 0.82 | ADORA2A (0.52) | ADORA2AADORA3PI4KAPI4K2BPI4K2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0472181-B1 | 5-Amine substituted adenosine analogs as immunosuppressants | MERRELL PHARMA INC (US) | 1996-10-02 | — | — | EP | disclosed |
| EP-0358536-B1 | Novel S-adenosyl methionine decarboxylase inhibitors | MERRELL PHARMA INC (US) | 1996-05-08 | — | — | EP | disclosed |
| US-5416076-A | S-adenosyl methionine decarboxylase inhibitors | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-05-16 | — | — | US | disclosed |
| US-5308837-A | 5'-amine substituted adenosine analogs as immunosuppressants | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-05-03 | — | — | US | disclosed |
| EP-0472181-A2 | 5-Amine substituted adenosine analogs as immunosuppressants | MERRELL PHARMACEUTICALS INC. (US) | 1992-02-26 | — | — | EP | disclosed |
| EP-0358536-A2 | Novel S-adenosyl methionine decarboxylase inhibitors | MERRELL PHARMACEUTICALS INC. (US) | 1990-03-14 | — | — | EP | disclosed |
| EP-0351475-A1 | S-Adenosylmethionine decarboxylase inhibitors | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-01-24 | — | — | EP | disclosed |