SCHEMBL8943869

SCHEMBL8943869

CNC(=O)c1cccc(-n2nnnc2S)c1

nearest known ligand 0.46

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TP53 P04637 4/20 0.46
KMT2A Q03164 4/20 0.46
MEN1 O00255 3/20 0.46
HDAC8 Q9BY41 1/20 0.45
HDAC6 Q9UBN7 1/20 0.45
SMN1; SMN2 Q16637 2/20 0.41
POLB P06746 1/20 0.38
HPGD P15428 1/20 0.38
KDM4E B2RXH2 2/20 0.38
MLYCD O95822 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
MAPT P10636 2/20 0.38
LMNA P02545 1/20 0.38
EPHX2 P34913 1/20 0.38
TSHR P16473 1/20 0.38
G6PD P11413 1/20 0.38
USP2 O75604 1/20 0.38
ALDH1A1 P00352 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13297855 0.88 HDAC8 (0.45) TP53KMT2AMEN1HDAC8HDAC6
SCHEMBL13297724 0.86 AOC2 (0.54) TP53KMT2AMEN1SMN1; SMN2POLB
SCHEMBL14498645 0.86 TP53 (0.49) TP53KMT2AMEN1SMN1; SMN2POLB
SCHEMBL14498646 0.85 TP53 (0.49) TP53KMT2AMEN1SMN1; SMN2POLB
SCHEMBL14160711 0.83 SMN1; SMN2 (0.46) TP53KMT2AMEN1HDAC8HDAC6
SCHEMBL8021678 0.83 TP53 (0.60) TP53KMT2AMEN1POLBHPGD
SCHEMBL14032683 0.81 TP53 (0.45) TP53KMT2AMEN1SMN1; SMN2POLB
SCHEMBL14498644 0.80 SMN1; SMN2 (0.52) TP53SMN1; SMN2HPGDMAPTLMNA
SCHEMBL5829255 0.79 KCNK3 (0.58) TP53KMT2AMEN1POLBMAPT
SCHEMBL1336437 0.79 ALDH1A1 (0.41) SMN1; SMN2POLBHPGDKDM4ENPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5589325-A METHINE DYE SENSITIZER FUJI PHOTO FILM CO., LTD. (JP) 1996-12-31 US disclosed