Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.77 |
| ▸ | MEN1 | O00255 | 3/20 | 0.77 |
| ▸ | TSHR | P16473 | 2/20 | 0.77 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.77 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.77 |
| ▸ | MAPT | P10636 | 1/20 | 0.77 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.77 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.77 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.77 |
| ▸ | LMNA | P02545 | 2/20 | 0.75 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.75 |
| ▸ | GMNN | O75496 | 1/20 | 0.75 |
| ▸ | BLM | P54132 | 1/20 | 0.75 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.75 |
| ▸ | HTR1A | P08908 | 1/20 | 0.64 |
| ▸ | HTR7 | P34969 | 1/20 | 0.64 |
| ▸ | RECQL | P46063 | 2/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27959848 | 0.88 | IGF1R (1.00) | IGF1RKMT2AMEN1TSHRCYP1A2 | |
| Brl-15,572 SCHEMBL7741355 | 0.87 | MEN1 (1.00) | IGF1RKMT2AMEN1TSHRCYP1A2 | |
| Brl-15,572 SCHEMBL17978413 | 0.86 | MEN1 (1.00) | IGF1RKMT2AMEN1TSHRCYP1A2 | |
| SCHEMBL1460309 | 0.85 | KMT2A (1.00) | IGF1RKMT2AMEN1MAPTHTR1A | |
| SCHEMBL25305786 | 0.82 | IGF1R (0.60) | IGF1RKMT2AMEN1TSHRCYP1A2 | |
| SCHEMBL10726186 | 0.81 | IGF1R (0.67) | IGF1RKMT2AMEN1TSHRCYP1A2 | |
| SCHEMBL10730411 | 0.81 | IGF1R (0.67) | IGF1RKMT2AMEN1TSHRCYP1A2 | |
| SCHEMBL11402774 | 0.79 | ADRA1D (0.69) | IGF1RKMT2AMEN1TSHRCYP1A2 | |
| SCHEMBL10746494 | 0.79 | GAA (0.82) | IGF1RKMT2AMEN1KDM4E | |
| SCHEMBL2796836 | 0.79 | GAA (0.82) | IGF1RKMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5541326-A | PHARMACEUTICAL COMPOSITION USED TO TREAT CENTRAL NERVOUS SYSTEM DISORDERS | JOHN WYETH & BROTHER, LIMITED (GB) | 1996-07-30 | — | — | US | disclosed |
| US-5420278-A | ω-(4-aryl or heteroarylpiperazine-1-yl)-2-aryl or aralkyl-propanoic or butanoic acids | JOHN WYETH & BROTHER, LIMITED (GB) | 1995-05-30 | — | — | US | disclosed |
| US-5382583-A | Hydroxytryptamine antagonists | JOHN WYETH & BROTHER, LIMITED (GB) | 1995-01-17 | — | — | US | disclosed |
| US-5340812-A | Antiserotonin. anxiolytic agents | JOHN WYETH & BROTHER, LIMITED (GB) | 1994-08-23 | — | — | US | disclosed |
| EP-0395312-A2 | Piperazine derivatives | JOHN WYETH & BROTHER LIMITED (GB) | 1990-10-31 | — | — | EP | disclosed |