Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CCR1 | P32246 | 2/20 | 0.39 |
| ▸ | CCR8 | P51685 | 2/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28648679 | 0.83 | LMNA (0.61) | LMNACYP3A4MAPTKDM4EHTT | |
| SCHEMBL8944497 | 0.83 | LMNA (0.61) | LMNACYP3A4MAPTKDM4EHTT | |
| SCHEMBL28653682 | 0.81 | LMNA (0.57) | LMNACYP3A4MAPTKDM4EHTT | |
| SCHEMBL28585914 | 0.81 | LMNA (0.57) | LMNACYP3A4MAPTKDM4EHTT | |
| SCHEMBL3673030 | 0.80 | LMNA (0.56) | LMNACYP3A4MAPTKDM4EHTT | |
| SCHEMBL322128 | 0.80 | LMNA (0.56) | LMNACYP3A4MAPTKDM4EHTT | |
| SCHEMBL16678778 | 0.78 | LMNA (0.54) | LMNACYP3A4MAPTKDM4EHTR2A | |
| SCHEMBL1669125 | 0.77 | LMNA (0.67) | LMNACYP3A4MAPTKDM4EHTT | |
| SCHEMBL7505756 | 0.77 | ALDH1A1 (0.45) | LMNACYP3A4MAPTKDM4EHTT | |
| SCHEMBL8313 | 0.76 | LMNA (1.00) | LMNACYP3A4MAPTKDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5545639-A | USING 2,9-BIS(HALOMETHYL)-1,10-PHENANTHROLINE | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1996-08-13 | — | — | US | disclosed |