Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8944584 | 0.88 | SIGMAR1 (0.47) | SIGMAR1MAOAMAOBNISCHLMNA | |
| SCHEMBL5557549 | 0.81 | SIGMAR1 (0.68) | SIGMAR1LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL5557553 | 0.81 | SIGMAR1 (0.68) | SIGMAR1LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL5556913 | 0.79 | SIGMAR1 (0.60) | SIGMAR1LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL5556907 | 0.79 | SIGMAR1 (0.60) | SIGMAR1LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL5557798 | 0.77 | KMT2A (0.55) | SIGMAR1LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL5557786 | 0.77 | KMT2A (0.55) | SIGMAR1LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL5558858 | 0.77 | ALDH1A1 (0.62) | SIGMAR1LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL5564360 | 0.77 | ALDH1A1 (0.62) | SIGMAR1LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL8944664 | 0.76 | NISCH (0.48) | SIGMAR1MAOAMAOBNISCH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0638568-B1 | Substituted piperazines, their process of preparation and the pharmaceutical compositions containing them | ADIR (FR) | 1996-10-09 | — | — | EP | disclosed |
| US-5500426-A | ADMINISTERED TO IMPROVE GLUCOSE TOLERANCE | ADIR ET COMPAGNIE (FR) | 1996-03-19 | — | — | US | disclosed |
| US-5492912-A | IMPROVES GLUCOSE TOLERANCE | ADIR ET COMPAGNIE (FR) | 1996-02-20 | — | — | US | disclosed |
| EP-0638568-A1 | Substituted piperazines, their process of preparation and the pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1995-02-15 | — | — | EP | disclosed |