Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8944843 | 0.87 | ALDH1A1 (0.57) | TSHRMAPK1RECQLKDM4EALDH1A1 | |
| SCHEMBL3306018 | 0.80 | MEN1 (0.54) | TSHRKDM4EALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL8944641 | 0.76 | ALDH1A1 (0.67) | TSHRMAPK1RECQLKDM4EALDH1A1 | |
| SCHEMBL8944884 | 0.76 | ALDH1A1 (0.57) | TSHRMAPK1RECQLKDM4EALDH1A1 | |
| SCHEMBL27628327 | 0.71 | ALDH1A1 (0.48) | TSHRALDH1A1POLBSMN1; SMN2MAPT | |
| SCHEMBL8877689 | 0.71 | TSHR (0.42) | TSHRMAPK1RECQLALDH1A1POLB | |
| SCHEMBL8877593 | 0.71 | TSHR (0.42) | TSHRMAPK1RECQLKDM4EALDH1A1 | |
| SCHEMBL9727236 | 0.71 | TSHR (0.57) | TSHRMAPK1RECQLKDM4EALDH1A1 | |
| SCHEMBL8944621 | 0.71 | KDM4E (0.44) | KDM4EALDH1A1POLBTDP1LMNA | |
| SCHEMBL8876826 | 0.70 | TSHR (0.46) | TSHRMAPK1RECQLALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0638568-B1 | Substituted piperazines, their process of preparation and the pharmaceutical compositions containing them | ADIR (FR) | 1996-10-09 | — | — | EP | disclosed |
| US-5500426-A | ADMINISTERED TO IMPROVE GLUCOSE TOLERANCE | ADIR ET COMPAGNIE (FR) | 1996-03-19 | — | — | US | disclosed |
| US-5492912-A | IMPROVES GLUCOSE TOLERANCE | ADIR ET COMPAGNIE (FR) | 1996-02-20 | — | — | US | disclosed |
| EP-0638568-A1 | Substituted piperazines, their process of preparation and the pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1995-02-15 | — | — | EP | disclosed |