Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.44 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8944641 | 0.88 | ALDH1A1 (0.67) | ALDH1A1KDM4EMAPK1TSHRRECQL | |
| SCHEMBL8944884 | 0.88 | ALDH1A1 (0.57) | ALDH1A1KDM4EMAPK1TSHRRECQL | |
| SCHEMBL8944705 | 0.87 | TSHR (0.56) | ALDH1A1KDM4EMAPK1TSHRRECQL | |
| SCHEMBL3306018 | 0.85 | MEN1 (0.54) | ALDH1A1KDM4ETSHRSMN1; SMN2MEN1 | |
| SCHEMBL8944874 | 0.81 | ALDH1A1 (0.54) | ALDH1A1KDM4EMAPK1TSHRRECQL | |
| SCHEMBL8944631 | 0.79 | ALDH1A1 (0.67) | ALDH1A1KDM4EMAPK1TSHRTDP1 | |
| SCHEMBL8944771 | 0.77 | P2RX7 (0.48) | ALDH1A1KDM4ETSHRGAACYP1A2 | |
| SCHEMBL8944618 | 0.77 | P2RX7 (0.48) | ALDH1A1TSHRGAACYP1A2CYP3A4 | |
| SCHEMBL27628327 | 0.77 | ALDH1A1 (0.48) | ALDH1A1TSHRSMN1; SMN2MAPTMEN1 | |
| SCHEMBL3309475 | 0.73 | MEN1 (0.54) | ALDH1A1KDM4ETSHRSMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0638568-B1 | Substituted piperazines, their process of preparation and the pharmaceutical compositions containing them | ADIR (FR) | 1996-10-09 | — | — | EP | disclosed |
| US-5500426-A | ADMINISTERED TO IMPROVE GLUCOSE TOLERANCE | ADIR ET COMPAGNIE (FR) | 1996-03-19 | — | — | US | disclosed |
| US-5492912-A | IMPROVES GLUCOSE TOLERANCE | ADIR ET COMPAGNIE (FR) | 1996-02-20 | — | — | US | disclosed |
| EP-0638568-A1 | Substituted piperazines, their process of preparation and the pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1995-02-15 | — | — | EP | disclosed |