SCHEMBL8944892

SCHEMBL8944892

Cc1ccc(S(=O)(=O)O[C@H]2[C@@H](O)[C@H](n3ccc(N)nc3=O)O[C@@H]2CO)cc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.61
MTOR P42345 2/20 0.61
THRB P10828 1/20 0.61
MDM2 Q00987 1/20 0.61
NCOA1 Q15788 1/20 0.61
NCOA3 Q9Y6Q9 1/20 0.61
L3MBTL1 Q9Y468 1/20 0.50
TSHR P16473 1/20 0.47
GLA P06280 1/20 0.47
PDE4D Q08499 1/20 0.45
PDE3A Q14432 1/20 0.45
SLC29A1 Q99808 1/20 0.45
NT5E P21589 1/20 0.43
ST6GAL1 P15907 3/20 0.42
P2RY2 P41231 1/20 0.42
GMNN O75496 1/20 0.41
ALDH1A1 P00352 1/20 0.41
TP53 P04637 1/20 0.41
NFKB1 P19838 1/20 0.41
DNMT1 P26358 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8944677 1.00 LMNA (0.61) LMNAMTORTHRBMDM2NCOA1
Alcohol SCHEMBL8944575 0.98 LMNA (0.59) LMNAMTORTHRBMDM2NCOA1
SCHEMBL8944594 0.91 L3MBTL1 (0.55) LMNAMTORTHRBMDM2NCOA1
SCHEMBL8944597 0.91 L3MBTL1 (0.55) LMNAMTORTHRBMDM2NCOA1
SCHEMBL8909115 0.86 LMNA (0.68) LMNAMTORTHRBMDM2NCOA1
SCHEMBL8909120 0.86 LMNA (0.68) LMNAMTORTHRBMDM2NCOA1
SCHEMBL2584050 0.86 LMNA (0.68) LMNAMTORTHRBMDM2NCOA1
Cytidine SCHEMBL29773203 0.83 LMNA (0.74) LMNAMTORTHRBMDM2NCOA1
SCHEMBL2785550 0.83 L3MBTL1 (0.66) LMNAMTORTHRBMDM2NCOA1
SCHEMBL2785549 0.83 L3MBTL1 (0.66) LMNAMTORTHRBMDM2NCOA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5536824-A INTERMEDIATES FOR 1-/B-D-XYLOPENTOFURANOSE/CYTOSINE, A DNA SYNTHESIS INHIBITOR ACIC (CANADA) INC. (CA) 1996-07-16 US disclosed
EP-0523080-B1 2,3'-O-CYCLOCYTIDINES, AND PROCESS FOR PRODUCTION THEREOF ACIC CANADA INC (CA) 1995-07-19 EP disclosed
US-5399682-A Cyclization ACIC (CANADA) INC. (CA) 1995-03-21 US disclosed
EP-0523080-A1 3'-O-TOSYLCYTIDINE AND CYTOSINE COMPOUNDS, AND PROCESS FOR PRODUCTION THEREOF. ACIC CANADA INC (CA) 1993-01-20 EP disclosed
WO-1991013901-A1 3'-O-TOSYLCYTIDINE AND CYTOSINE COMPOUNDS, AND PROCESS FOR PRODUCTION THEREOF ACIC (CANADA) INC. (CA) 1991-09-19 WO disclosed