SCHEMBL8944898

SCHEMBL8944898

C=CCNc1cccc2cccc(NCC=C)c12

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 0.42
MEN1 O00255 2/20 0.42
RRM2 P31350 1/20 0.39
ALOX12 P18054 2/20 0.39
TDP1 Q9NUW8 1/20 0.39
ALDH1A1 P00352 6/20 0.38
CA12 O43570 2/20 0.36
CA1 P00915 2/20 0.36
CA2 P00918 2/20 0.36
CA9 Q16790 2/20 0.36
CA14 Q9ULX7 1/20 0.36
RAB9A P51151 4/20 0.35
KDM4E B2RXH2 4/20 0.35
SMN1; SMN2 Q16637 3/20 0.35
HPGD P15428 3/20 0.35
MAPT P10636 3/20 0.35
GAA P10253 2/20 0.35
NSD2 O96028 2/20 0.35
MITF O75030 1/20 0.35
LMNA P02545 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31483890 0.87 ALDH1A1 (0.42) KMT2AMEN1RRM2ALOX12TDP1
SCHEMBL9158714 0.87 RRM2 (0.38) KMT2AMEN1RRM2ALOX12TDP1
SCHEMBL7633773 0.83 ADRB2 (0.44) KMT2AMEN1ALOX12TDP1ALDH1A1
SCHEMBL9162028 0.82 KMT2A (0.35) KMT2AMEN1RRM2ALOX12TDP1
SCHEMBL31497264 0.80 KMT2A (0.59) KMT2AMEN1ALOX12TDP1ALDH1A1
SCHEMBL896623 0.80 KMT2A (0.59) KMT2AMEN1ALOX12TDP1ALDH1A1
SCHEMBL4784858 0.80 ALDH1A1 (0.44) KMT2AMEN1RRM2ALDH1A1CA12
SCHEMBL5549248 0.78 RRM2 (0.38) KMT2AMEN1RRM2ALOX12TDP1
SCHEMBL9157046 0.78 KMT2A (0.45) KMT2AMEN1RRM2ALOX12TDP1
SCHEMBL17865619 0.77 ALDH1A1 (0.37) KMT2AMEN1RRM2ALDH1A1CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0512954-B1 Substituted naphthalenediamine stabilizers CIBA GEIGY AG (CH) 1995-03-08 EP claimed
US-5198134-A Antioxidants for lubricants CIBA-GEIGY CORPORATION (US) 1993-03-30 US claimed
EP-0512954-A1 Substituted naphthalenediamine stabilizers CIBA-GEIGY AG (CH) 1992-11-11 EP claimed
US-5097029-A Hydrolysis, alkylation, intermediates for azo dyes HERCULES INCORPORATED (US) 1992-03-17 US claimed
EP-0406812-A2 Process for the preparation of NiNi-dialkyl-1,8-naphthalene diamine HERCULES INCORPORATED (US) 1991-01-09 EP claimed
US-5589100-A LIQUID CRYSTAL DISPLAY SUBSTRATES WITH ARYLAZO OR POLYARYLAZO DYES HERCULES INCORPORATED (US) 1996-12-31 US disclosed
EP-0512954-B1 Substituted naphthalenediamine stabilizers CIBA GEIGY AG (CH) 1995-03-08 EP disclosed
EP-0406812-B1 Process for the preparation of NiNi-dialkyl-1,8-naphthalene diamine HERCULES INC (US) 1995-02-15 EP disclosed
US-5326865-A Arylazo and poly(arylazo) dyes having at least one core radical selected from naphthyl or anthracyl and having at least one 2,3-dihydro-1,3-dialkyl perimidine substituent HERCULES INCORPORATED (US) 1994-07-05 US disclosed
EP-0460504-B1 Dichroic azo dyes HERCULES INC (US) 1994-04-27 EP disclosed
US-5198134-A Antioxidants for lubricants CIBA-GEIGY CORPORATION (US) 1993-03-30 US disclosed
US-5097029-A Hydrolysis, alkylation, intermediates for azo dyes HERCULES INCORPORATED (US) 1992-03-17 US disclosed
US-5097029-A Hydrolysis, alkylation, intermediates for azo dyes HERCULES INCORPORATED (US) 1992-03-17 US disclosed
EP-0460504-A1 Dichroic azo dyes HERCULES INCORPORATED (US) 1991-12-11 EP disclosed
EP-0406812-A2 Process for the preparation of NiNi-dialkyl-1,8-naphthalene diamine HERCULES INCORPORATED (US) 1991-01-09 EP disclosed