SCHEMBL8944899

SCHEMBL8944899

NC(=O)OCC(N)COc1noc2cc(Cl)ccc12

nearest known ligand 0.49

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.49
ALDH1A1 P00352 1/20 0.49
CYP1A2 P05177 1/20 0.40
FAAH O00519 1/20 0.39
TP53 P04637 1/20 0.33
ALOX15 P16050 1/20 0.33
TSHR P16473 1/20 0.33
KCNJ6 P48051 1/20 0.33
KCNJ3 P48549 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
ABCC9 O60706 1/20 0.33
MAPT P10636 2/20 0.33
MEN1 O00255 1/20 0.32
P2RX3 P56373 1/20 0.32
HTR2A P28223 2/20 0.32
HTR7 P34969 1/20 0.32
KMO O15229 1/20 0.32
MAOB P27338 1/20 0.31
DRD3 P35462 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8945107 0.91 FAAH (0.49) KMT2AALDH1A1CYP1A2FAAHTP53
Hydrochloric Acid SCHEMBL8945060 0.90 FAAH (0.48) KMT2AALDH1A1CYP1A2FAAHTP53
Hydrochloric Acid SCHEMBL8945392 0.85 MAPT (0.36) KMT2AALDH1A1CYP1A2FAAHTP53
SCHEMBL8944960 0.83 FAAH (0.45) KMT2AALDH1A1CYP1A2FAAHTP53
Hydrochloric Acid SCHEMBL8945261 0.82 FAAH (0.44) KMT2AALDH1A1CYP1A2FAAHTP53
Hydrochloric Acid SCHEMBL8945510 0.82 FAAH (0.44) KMT2AALDH1A1CYP1A2FAAHTP53
Hydrochloric Acid SCHEMBL8945062 0.80 FAAH (0.46) KMT2AALDH1A1CYP1A2FAAHTP53
SCHEMBL8945144 0.80 FAAH (0.50) KMT2AALDH1A1CYP1A2FAAHTP53
SCHEMBL8944906 0.79 CYP1A2 (0.35) KMT2AALDH1A1CYP1A2FAAHTP53
SCHEMBL8945112 0.79 CYP1A2 (0.34) ALDH1A1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5578627-A FOR TREATING CEREBRAL CIRCULATORY DISORDER, HEAD INJURY SEQUELAE AND/OR EPILEPSY TOYAMA CHEMICAL CO., LTD. (JP) 1996-11-26 US disclosed
EP-0665226-A1 NOVEL 1,2-BENZISOXAZOLE DERIVATIVE OR SALT THEREOF, AND BRAIN PROTECTIVE AGENT COMPRISING THE SAME TOYAMA CHEMICAL CO., LTD. (JP) 1995-08-02 EP disclosed