⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1400976 | 0.91 | HTR2C (0.36) | — | |
| SCHEMBL11968955 | 0.91 | HTR6 (0.45) | — | |
| SCHEMBL3534078 | 0.89 | HTR6 (0.44) | — | |
| SCHEMBL1268607 | 0.68 | — | — | |
| SCHEMBL23478571 | 0.68 | — | — | |
| SCHEMBL2007511 | 0.68 | — | — | |
| SCHEMBL6743417 | 0.67 | HTR6 (0.44) | — | |
| SCHEMBL9784554 | 0.67 | — | — | |
| SCHEMBL2265420 | 0.64 | HTR2C (0.33) | — | |
| SCHEMBL9936712 | 0.62 | LMNA (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440204-B1 | NICOTINAMIDE COMPOUNDS USEFUL AS KINASE MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2013-12-18 | — | — | EP | claimed |
| US-8586751-B2 | Nicotinamide compounds useful as kinase modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-11-19 | — | — | US | claimed |
| CN-102458402-B | Nicotinamide compounds useful as kinase modulators | BRISTOL MYERS SQUIBB CO | 2013-10-02 | — | — | CN | claimed |
| CN-102458402-A | Nicotinamide compounds useful as kinase modulators | BRISTOL MYERS SQUIBB CO | 2012-05-16 | — | — | CN | claimed |
| EP-2440204-A1 | NICOTINAMIDE COMPOUNDS USEFUL AS KINASE MODULATORS | Bristol-Myers Squibb Company (US) | 2012-04-18 | — | — | EP | claimed |
| US-20120082702-A1 | NICOTINAMIDE COMPOUNDS USEFUL AS KINASE MODULATORS | BRISTOL-MEYERS SQUIBB COMPANY | 2012-04-05 | — | — | US | claimed |
| WO-2010144647-A1 | NICOTINAMIDE COMPOUNDS USEFUL AS KINASE MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-12-16 | — | — | WO | claimed |
| EP-2440204-B1 | NICOTINAMIDE COMPOUNDS USEFUL AS KINASE MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2013-12-18 | — | — | EP | disclosed |
| US-8586751-B2 | Nicotinamide compounds useful as kinase modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-11-19 | — | — | US | disclosed |
| CN-102458402-B | Nicotinamide compounds useful as kinase modulators | BRISTOL MYERS SQUIBB CO | 2013-10-02 | — | — | CN | disclosed |
| CN-102458402-A | Nicotinamide compounds useful as kinase modulators | BRISTOL MYERS SQUIBB CO | 2012-05-16 | — | — | CN | disclosed |
| EP-2440204-A1 | NICOTINAMIDE COMPOUNDS USEFUL AS KINASE MODULATORS | Bristol-Myers Squibb Company (US) | 2012-04-18 | — | — | EP | disclosed |
| US-20120082702-A1 | NICOTINAMIDE COMPOUNDS USEFUL AS KINASE MODULATORS | BRISTOL-MEYERS SQUIBB COMPANY | 2012-04-05 | — | — | US | disclosed |
| WO-2010144647-A1 | NICOTINAMIDE COMPOUNDS USEFUL AS KINASE MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-12-16 | — | — | WO | disclosed |