Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11154268 | 0.78 | NPC1 (0.41) | SLC6A2SLC6A4SLC6A3SMN1; SMN2ALDH1A1 | |
| SCHEMBL8945774 | 0.77 | SLC6A2 (0.40) | SLC6A2SLC6A4SLC6A3NOS3NOS2 | |
| Hydrochloric Acid SCHEMBL9581759 | 0.77 | NPC1 (0.44) | SLC6A2SLC6A4SLC6A3KDM4ESMN1; SMN2 | |
| SCHEMBL8946091 | 0.74 | SLC6A2 (0.38) | SLC6A2SLC6A4SLC6A3NOS3NOS2 | |
| SCHEMBL8945788 | 0.74 | MEN1 (0.38) | SLC6A2SLC6A4SLC6A3NOS3NOS2 | |
| Hydrochloric Acid SCHEMBL8946092 | 0.73 | MEN1 (0.37) | SLC6A2SLC6A4SLC6A3NOS3NOS2 | |
| Hydrochloric Acid SCHEMBL8945737 | 0.73 | SLC6A2 (0.37) | SLC6A2SLC6A4SLC6A3NOS3NOS2 | |
| SCHEMBL8945770 | 0.72 | SLC6A2 (0.36) | SLC6A2SLC6A4SLC6A3NOS3NOS2 | |
| Hydrochloric Acid SCHEMBL8945853 | 0.71 | SLC6A2 (0.36) | SLC6A2SLC6A4SLC6A3NOS3NOS2 | |
| SCHEMBL8945814 | 0.69 | GAA (0.44) | KDM4EMEN1KMT2AL3MBTL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5510346-A | ANTIDEPRESSANTS, ANTIANXIETY AGENTS | HOECHST MARION ROUSSEL, INC. (US) | 1996-04-23 | — | — | US | disclosed |
| US-5292760-A | 4-heteroaryl-1,3-benzodiazepines and 2-substituted-α-(heteroaryl)benzeneethanamines | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0322582-A2 | 4-Heteroaryl-1,3-Benzodiazepines and 2-substituted-alpha-(heteroaryl)benzeneethanamines, a process for their preparation and their use us medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1989-07-05 | — | — | EP | disclosed |