Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | MMP13 | P45452 | 2/20 | 0.39 |
| ▸ | NMT1 | P30419 | 2/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8946054 | 0.90 | MEN1 (0.41) | MEN1HSP90AA1KMT2ASRD5A2MAOB | |
| SCHEMBL8946223 | 0.88 | MEN1 (0.44) | BCHEMEN1HSP90AA1KMT2ASRD5A2 | |
| SCHEMBL7621050 | 0.86 | BCHE (0.51) | BCHEMEN1KMT2ASRD5A2ROCK1 | |
| Hydrochloric Acid SCHEMBL8544417 | 0.85 | BCHE (0.51) | BCHEMEN1KMT2ASRD5A2ROCK1 | |
| SCHEMBL8946048 | 0.84 | BCHE (0.44) | BCHEMEN1KMT2ASRD5A2ROCK1 | |
| SCHEMBL8946085 | 0.84 | SLC6A2 (0.47) | BCHEMEN1KMT2AALDH1A1 | |
| SCHEMBL9674458 | 0.76 | ROCK1 (0.46) | MEN1KMT2ASRD5A2ROCK1 | |
| SCHEMBL8946151 | 0.74 | MEN1 (0.47) | BCHEMEN1HSP90AA1KMT2ASRD5A2 | |
| SCHEMBL8946189 | 0.74 | ROCK1 (0.43) | MEN1KMT2ASRD5A2ROCK1 | |
| SCHEMBL8539041 | 0.73 | SLC6A2 (0.71) | MEN1KMT2ASRD5A2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0509400-B1 | 1-(Pyrido[3,4-b]-1,4-oxazinyl-4-yl)-1H-indoles, intermediates and a process for their preparation, and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1996-07-03 | — | — | EP | disclosed |
| US-5519131-A | CYCLIZATION OF HYDROXYALKYLAMINO COMPOUND IN THE PRESENCE OF STRONG BASE SUCH AS SODIUM HYDRIDE OR POTASSIUM TERT-BUTOXIDE | HOECHST MARION ROUSSEL INC. (US) | 1996-05-21 | — | — | US | disclosed |
| US-5276156-A | Antidepressants, treatment of Alzheimer*s disease | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1994-01-04 | — | — | US | disclosed |
| US-5214038-A | Cholinesterase inhibitors, antidepressants, cognition activators | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1993-05-25 | — | — | US | disclosed |
| EP-0509400-A1 | 1-(Pyrido[3,4-b]-1,4-oxazinyl-4-yl)-1H-indoles, intermediates and a process for their preparation, and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-10-21 | — | — | EP | disclosed |