Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8946338 | 1.00 | AURKA (0.41) | AURKAAURKBALDH1A1HPGDMAPT | |
| SCHEMBL8946332 | 1.00 | AURKA (0.41) | AURKAAURKBALDH1A1HPGDMAPT | |
| SCHEMBL8946425 | 0.82 | AURKA (0.42) | AURKAAURKBALDH1A1HPGDMAPT | |
| SCHEMBL8946430 | 0.82 | AURKA (0.42) | AURKAAURKBALDH1A1HPGDMAPT | |
| SCHEMBL8946422 | 0.82 | AURKA (0.42) | AURKAAURKBALDH1A1HPGDMAPT | |
| SCHEMBL8946459 | 0.81 | HPGD (0.49) | ALDH1A1HPGDMAPTKDM4EMAPK1 | |
| SCHEMBL8946466 | 0.81 | HPGD (0.49) | ALDH1A1HPGDMAPTKDM4EMAPK1 | |
| SCHEMBL9844735 | 0.75 | KDM4E (0.45) | ALDH1A1HPGDMAPTKDM4EMAPK1 | |
| SCHEMBL8946638 | 0.72 | MAPT (0.42) | AURKAAURKBALDH1A1HPGDMAPT | |
| SCHEMBL8946631 | 0.72 | MAPT (0.42) | AURKAAURKBALDH1A1HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0409410-B1 | Indenoindole compounds | UNIV BATH (GB) | 1996-03-20 | — | — | EP | claimed |
| US-5516788-A | TREATMENT OF ATHEROSCLEROSIS; ANTIISCHEMIC, ANTICARCINOGENIC AGENTS; ANTICOAGULANTS | UNIVERSITY OF BATH (GB) | 1996-05-14 | — | — | US | disclosed |
| EP-0409410-B1 | Indenoindole compounds | UNIV BATH (GB) | 1996-03-20 | — | — | EP | disclosed |