Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | HTR2B | P41595 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8946463 | 1.00 | HPGD (0.49) | HPGDKDM4EALDH1A1LMNAMAPT | |
| SCHEMBL8946466 | 1.00 | HPGD (0.49) | HPGDKDM4EALDH1A1LMNAMAPT | |
| SCHEMBL8946482 | 0.84 | HPGD (0.45) | HPGDKDM4EALDH1A1LMNAMAPT | |
| SCHEMBL8946962 | 0.84 | HPGD (0.45) | HPGDKDM4EALDH1A1LMNAMAPT | |
| SCHEMBL8946958 | 0.84 | HPGD (0.45) | HPGDKDM4EALDH1A1LMNAMAPT | |
| SCHEMBL9844735 | 0.82 | KDM4E (0.45) | HPGDKDM4EALDH1A1LMNAMAPT | |
| SCHEMBL8946338 | 0.81 | AURKA (0.41) | HPGDKDM4EALDH1A1LMNAMAPT | |
| SCHEMBL8946332 | 0.81 | AURKA (0.41) | HPGDKDM4EALDH1A1LMNAMAPT | |
| SCHEMBL8946327 | 0.81 | AURKA (0.41) | HPGDKDM4EALDH1A1LMNAMAPT | |
| SCHEMBL8946343 | 0.72 | HPGD (0.78) | HPGDKDM4EALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0409410-B1 | Indenoindole compounds | UNIV BATH (GB) | 1996-03-20 | — | — | EP | claimed |
| US-5516788-A | TREATMENT OF ATHEROSCLEROSIS; ANTIISCHEMIC, ANTICARCINOGENIC AGENTS; ANTICOAGULANTS | UNIVERSITY OF BATH (GB) | 1996-05-14 | — | — | US | disclosed |
| EP-0409410-B1 | Indenoindole compounds | UNIV BATH (GB) | 1996-03-20 | — | — | EP | disclosed |
| EP-0409410-A1 | Indenoindole compounds | UNIVERSITY OF BATH (GB) | 1991-01-23 | — | — | EP | disclosed |
| WO-1990015799-A1 | INDENOINDOLE COMPOUNDS II | UNIVERSITY OF BATH (GB) | 1990-12-27 | — | — | WO | disclosed |