Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.30 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.30 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.30 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.30 |
| ▸ | HTR1D | P28221 | 1/20 | 0.30 |
| ▸ | HTR1B | P28222 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8946358 | 1.00 | KDM4E (0.33) | KDM4EALDH1A1LMNAMAPTHPGD | |
| SCHEMBL8946353 | 1.00 | KDM4E (0.33) | KDM4EALDH1A1LMNAMAPTHPGD | |
| Indole SCHEMBL9739454 | 0.89 | TRPA1 (0.35) | — | |
| SCHEMBL8946604 | 0.82 | KDM4E (0.37) | KDM4EALDH1A1LMNAMAPTHPGD | |
| SCHEMBL8946594 | 0.82 | KDM4E (0.37) | KDM4EALDH1A1LMNAMAPTHPGD | |
| SCHEMBL8946600 | 0.82 | KDM4E (0.37) | KDM4EALDH1A1LMNAMAPTHPGD | |
| SCHEMBL8946717 | 0.80 | ALDH1A1 (0.39) | KDM4EALDH1A1LMNAMAPTHPGD | |
| SCHEMBL8946709 | 0.80 | ALDH1A1 (0.39) | KDM4EALDH1A1LMNAMAPTHPGD | |
| SCHEMBL8946715 | 0.80 | ALDH1A1 (0.39) | KDM4EALDH1A1LMNAMAPTHPGD | |
| SCHEMBL8946281 | 0.71 | HTR2A (0.39) | KDM4EALDH1A1LMNAMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516788-A | TREATMENT OF ATHEROSCLEROSIS; ANTIISCHEMIC, ANTICARCINOGENIC AGENTS; ANTICOAGULANTS | UNIVERSITY OF BATH (GB) | 1996-05-14 | — | — | US | claimed |
| EP-0481708-A1 | Indenoindole compounds | UNIVERSITY OF BATH (GB) | 1992-04-22 | — | — | EP | claimed |
| US-5516788-A | TREATMENT OF ATHEROSCLEROSIS; ANTIISCHEMIC, ANTICARCINOGENIC AGENTS; ANTICOAGULANTS | UNIVERSITY OF BATH (GB) | 1996-05-14 | — | — | US | disclosed |
| EP-0481708-A1 | Indenoindole compounds | UNIVERSITY OF BATH (GB) | 1992-04-22 | — | — | EP | disclosed |