Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | SNCA | P37840 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | WDR5 | P61964 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.39 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8946666 | 0.85 | MAPT (0.49) | MAPTKDM4ELMNAALDH1A1GAA | |
| SCHEMBL8946659 | 0.85 | MAPT (0.49) | MAPTKDM4ELMNAALDH1A1GAA | |
| SCHEMBL8946662 | 0.85 | MAPT (0.49) | MAPTKDM4ELMNAALDH1A1GAA | |
| SCHEMBL8946434 | 0.81 | HSD17B3 (0.44) | MAPTLMNAALDH1A1CREBBPHTT | |
| SCHEMBL8946587 | 0.78 | KDM4E (0.49) | MAPTKDM4EALDH1A1CREBBPPOLB | |
| SCHEMBL8946786 | 0.76 | CREBBP (0.40) | MAPTLMNAALDH1A1GAACREBBP | |
| SCHEMBL7416582 | 0.70 | KDM4E (0.67) | MAPTKDM4ELMNAALDH1A1HTT | |
| SCHEMBL5798736 | 0.70 | MAPT (0.67) | MAPTKDM4ELMNAALDH1A1GAA | |
| SCHEMBL16135452 | 0.68 | MAPT (0.51) | MAPTKDM4ESNCALMNAALDH1A1 | |
| SCHEMBL6971552 | 0.68 | MAPT (0.51) | MAPTKDM4ESNCALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516788-A | TREATMENT OF ATHEROSCLEROSIS; ANTIISCHEMIC, ANTICARCINOGENIC AGENTS; ANTICOAGULANTS | UNIVERSITY OF BATH (GB) | 1996-05-14 | — | — | US | disclosed |
| EP-0409410-B1 | Indenoindole compounds | UNIV BATH (GB) | 1996-03-20 | — | — | EP | disclosed |
| WO-1990015799-A1 | INDENOINDOLE COMPOUNDS II | UNIVERSITY OF BATH (GB) | 1990-12-27 | — | — | WO | disclosed |