Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B3 | P37058 | 1/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.42 |
| ▸ | FSHR | P23945 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | PAK4 | O96013 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8946692 | 0.83 | HSD17B3 (0.39) | HSD17B3CREBBPNOTUMFSHRALDH1A1 | |
| SCHEMBL8946697 | 0.83 | HSD17B3 (0.39) | HSD17B3CREBBPNOTUMFSHRALDH1A1 | |
| SCHEMBL8946705 | 0.83 | HSD17B3 (0.39) | HSD17B3CREBBPNOTUMFSHRALDH1A1 | |
| SCHEMBL8946587 | 0.82 | KDM4E (0.49) | CREBBPNOTUMALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL8946435 | 0.81 | MAPT (0.47) | CREBBPNOTUMALDH1A1LMNAMAPT | |
| SCHEMBL8946786 | 0.80 | CREBBP (0.40) | CREBBPNOTUMALDH1A1LMNAMAPT | |
| SCHEMBL21371548 | 0.69 | NOTUM (0.40) | HSD17B3CREBBPNOTUMALDH1A1LMNA | |
| SCHEMBL15383120 | 0.69 | NOTUM (0.40) | HSD17B3CREBBPNOTUMALDH1A1LMNA | |
| SCHEMBL7416927 | 0.67 | NOTUM (0.62) | HSD17B3NOTUMLMNAMAPTSMN1; SMN2 | |
| SCHEMBL5798751 | 0.67 | NOTUM (0.62) | HSD17B3NOTUMLMNAMAPTBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516788-A | TREATMENT OF ATHEROSCLEROSIS; ANTIISCHEMIC, ANTICARCINOGENIC AGENTS; ANTICOAGULANTS | UNIVERSITY OF BATH (GB) | 1996-05-14 | — | — | US | disclosed |
| EP-0409410-B1 | Indenoindole compounds | UNIV BATH (GB) | 1996-03-20 | — | — | EP | disclosed |
| EP-0409410-A1 | Indenoindole compounds | UNIVERSITY OF BATH (GB) | 1991-01-23 | — | — | EP | disclosed |
| WO-1990015799-A1 | INDENOINDOLE COMPOUNDS II | UNIVERSITY OF BATH (GB) | 1990-12-27 | — | — | WO | disclosed |