Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 16/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TNKS | O95271 | 1/20 | 0.34 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.34 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018957 | 1.00 | KIF11 (0.39) | KIF11ALDH1A1TNKSTNKS2PARP3 | |
| SCHEMBL9018954 | 1.00 | KIF11 (0.39) | KIF11ALDH1A1TNKSTNKS2PARP3 | |
| SCHEMBL8946330 | 0.78 | OPRM1 (0.42) | ALDH1A1BRD4CREBBP | |
| SCHEMBL8946325 | 0.78 | OPRM1 (0.42) | ALDH1A1BRD4CREBBP | |
| SCHEMBL8946320 | 0.78 | OPRM1 (0.42) | ALDH1A1BRD4CREBBP | |
| SCHEMBL8946515 | 0.78 | OPRM1 (0.38) | — | |
| SCHEMBL8946513 | 0.78 | OPRM1 (0.38) | — | |
| SCHEMBL8946517 | 0.78 | OPRM1 (0.38) | — | |
| SCHEMBL8946481 | 0.78 | HTR2A (0.46) | ALDH1A1 | |
| SCHEMBL8946471 | 0.78 | HTR2A (0.46) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516788-A | TREATMENT OF ATHEROSCLEROSIS; ANTIISCHEMIC, ANTICARCINOGENIC AGENTS; ANTICOAGULANTS | UNIVERSITY OF BATH (GB) | 1996-05-14 | — | — | US | disclosed |
| EP-0409410-B1 | Indenoindole compounds | UNIV BATH (GB) | 1996-03-20 | — | — | EP | disclosed |
| EP-0409410-A1 | Indenoindole compounds | UNIVERSITY OF BATH (GB) | 1991-01-23 | — | — | EP | disclosed |
| WO-1990015799-A1 | INDENOINDOLE COMPOUNDS II | UNIVERSITY OF BATH (GB) | 1990-12-27 | — | — | WO | disclosed |