Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8946511 | 1.00 | ALDH1A1 (0.35) | ALDH1A1TP53SIGMAR1MAPTBACE1 | |
| SCHEMBL8946501 | 1.00 | ALDH1A1 (0.35) | ALDH1A1TP53SIGMAR1MAPTBACE1 | |
| SCHEMBL8946525 | 0.84 | BACE1 (0.35) | ALDH1A1TP53MAPTBACE1PDK2 | |
| SCHEMBL8946533 | 0.84 | BACE1 (0.35) | ALDH1A1TP53MAPTBACE1PDK2 | |
| SCHEMBL8946531 | 0.84 | BACE1 (0.35) | ALDH1A1TP53MAPTBACE1PDK2 | |
| SCHEMBL8946704 | 0.81 | S100B (0.34) | ALDH1A1TP53 | |
| SCHEMBL8946701 | 0.81 | S100B (0.34) | ALDH1A1TP53 | |
| SCHEMBL8946695 | 0.81 | S100B (0.34) | ALDH1A1TP53 | |
| SCHEMBL8946412 | 0.79 | BACE1 (0.36) | ALDH1A1TP53MAPTBACE1POLB | |
| SCHEMBL8946423 | 0.79 | BACE1 (0.36) | ALDH1A1TP53MAPTBACE1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516788-A | TREATMENT OF ATHEROSCLEROSIS; ANTIISCHEMIC, ANTICARCINOGENIC AGENTS; ANTICOAGULANTS | UNIVERSITY OF BATH (GB) | 1996-05-14 | — | — | US | disclosed |
| EP-0409410-B1 | Indenoindole compounds | UNIV BATH (GB) | 1996-03-20 | — | — | EP | disclosed |
| EP-0409410-A1 | Indenoindole compounds | UNIVERSITY OF BATH (GB) | 1991-01-23 | — | — | EP | disclosed |