Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | GPR3 | P46089 | 1/20 | 0.37 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8946743 | 1.00 | ADRA2A (0.41) | ADRA2AADRA2BADRA2CSLC6A2HTR2A | |
| SCHEMBL8946720 | 1.00 | ADRA2A (0.41) | ADRA2AADRA2BADRA2CSLC6A2HTR2A | |
| SCHEMBL8946433 | 0.84 | SLC6A2 (0.40) | SLC6A2HTR2AHTR2CSLC6A4ADRA1A | |
| SCHEMBL8946437 | 0.84 | SLC6A2 (0.40) | SLC6A2HTR2AHTR2CSLC6A4ADRA1A | |
| SCHEMBL8946442 | 0.84 | SLC6A2 (0.40) | SLC6A2HTR2AHTR2CSLC6A4ADRA1A | |
| SCHEMBL24300090 | 0.83 | OPRM1 (0.41) | SLC6A2HTR2AHTR2CSLC6A4HTR2B | |
| SCHEMBL8946497 | 0.81 | KDM4E (0.43) | ADRA2AADRA2BADRA2CSLC6A2HTR2A | |
| SCHEMBL8946972 | 0.81 | HTR2A (0.45) | SLC6A2HTR2ASLC6A4OPRM1 | |
| SCHEMBL8946506 | 0.81 | KDM4E (0.43) | ADRA2AADRA2BADRA2CSLC6A2HTR2A | |
| SCHEMBL8946988 | 0.81 | HTR2A (0.45) | SLC6A2HTR2ASLC6A4OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516788-A | TREATMENT OF ATHEROSCLEROSIS; ANTIISCHEMIC, ANTICARCINOGENIC AGENTS; ANTICOAGULANTS | UNIVERSITY OF BATH (GB) | 1996-05-14 | — | — | US | disclosed |
| EP-0409410-B1 | Indenoindole compounds | UNIV BATH (GB) | 1996-03-20 | — | — | EP | disclosed |
| EP-0409410-A1 | Indenoindole compounds | UNIVERSITY OF BATH (GB) | 1991-01-23 | — | — | EP | disclosed |
| WO-1990015799-A1 | INDENOINDOLE COMPOUNDS II | UNIVERSITY OF BATH (GB) | 1990-12-27 | — | — | WO | disclosed |