Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 6/20 | 0.61 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | RARA | P10276 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | MTOR | P42345 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | ESR1 | P03372 | 2/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.50 |
| ▸ | TACR2 | P21452 | 2/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3031498 | 0.93 | CA2 (0.59) | RARBCA1CA2ALDH1A1HSD17B10 | |
| SCHEMBL11894717 | 0.91 | RARB (0.52) | RARBCA1CA2ALDH1A1MEN1 | |
| SCHEMBL28829434 | 0.89 | RARB (0.67) | RARBCA1CA2ALDH1A1MEN1 | |
| SCHEMBL5551587 | 0.89 | RARB (0.67) | RARBCA1CA2ALDH1A1MEN1 | |
| SCHEMBL3535251 | 0.89 | CA2 (0.54) | RARBCA2ALDH1A1MEN1RARA | |
| SCHEMBL8500578 | 0.86 | ALDH1A1 (0.59) | CA1CA2ALDH1A1HSD17B10HPGD | |
| SCHEMBL6287871 | 0.86 | ALDH1A1 (0.65) | ALDH1A1MEN1KMT2AHSD17B10ESR1 | |
| SCHEMBL28900119 | 0.86 | RARB (0.64) | RARBCA1CA2ALDH1A1MEN1 | |
| SCHEMBL17193544 | 0.85 | RARB (0.54) | RARBALDH1A1MEN1RARAMAPT | |
| SCHEMBL10001878 | 0.85 | RARB (0.51) | RARBCA1CA2ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5567841-A | ANTICHOLESTEROL AGENT | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-10-22 | — | — | US | disclosed |
| US-5470845-A | Methods of using α-phosphonosulfonate squalene synthetase inhibitors including the treatment of atherosclerosis and hypercholesterolemia | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-11-28 | — | — | US | disclosed |